Recurrence of Gastric Ulcer Dependent Upon Strain Differences of Helicobacter pylori in Urease B Gene |
| |
Authors: | Hidetaka Matsui Yoshikazu Kubo Tomoyuki Ninomiya Yuji Mizukami Morikazu Onji |
| |
Affiliation: | (1) Third Department of Internal Medicine, Ehime University School of Medicine, Shitsukawa, Shigenobu-cho, Onsen-gun, Ehime, 791-0295, Japan |
| |
Abstract: | To evaluate the role of different strains of Helicobacter pylori on the recurrence of gastric ulcer, we divided H. pylori into four types (I, II, III, and IV) according to the urease B gene using polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP). The relationship between the recurrence of gastric ulcer and the prevalence of H. pylori types was studied in 32 patients with benign open gastric ulcers using upper gastrointestinal endoscopy. The rate of recurrence was significantly lower in patients with type II than in patients with types I, III, and IV (P < 0.05). Using Mongolian gerbils, an animal model of H. pylori infection, we also showed that the occurrence of gastric ulceration following restraint water-immersion stress was significantly lower in type II compared with types I and III. These data indicate that in the context of ulcer recurrence, it is not necessary to eradicate H. pylori during infection with type II. |
| |
Keywords: | Helicobacter pylori urease B gene polymerase chain reaction– restriction fragment length polymorphism nonrecurrent gastric ulcer Mongolian gerbils |
本文献已被 PubMed SpringerLink 等数据库收录! |
|