腹腔镜术后肺损伤及miRNA的表达

【摘要】〓腹腔镜手术是近年来发展迅速的微创外科术式,具有创伤小、恢复快等特点,然而手术过程中建立CO²气腹所造成的腹腔内高压及酸碱平衡失调等因素均会引起肺组织损伤,导致术后肺功能不全,重者甚至可发展成为呼吸功能衰竭。微小RNA(miRNA)作为一类小分子的非编码调控RNA,在多个层面的生命过程中起调节作用,研究表明miRNA与各种肺部疾病的发生、发展及转归有密切的联系。随着腹腔镜技术的成熟和普及,腹腔镜术后肺损伤问题日益突显,更好地探索并理解其发生机制以及miRNA在其中发挥的作用,能为我们日后的诊断和治疗提供更好的依据。本文将就近年来国内外有关腹腔镜术后肺损伤机制以及miRNA在其中可能发挥的作用作简要阐述。

Pulmomary impairment and miRNA expressions after laparoscopic operation

【Abstract】〓Laparoscopic surgery has developed rapidly in recent years as a crucial component of minimally invasive surgery,with the characteristics of lower trauma and faster recovery. Nevertheless the high intra-abdominal pressure and acid-base balance disorder caused by CO2 pneumoperitoneum can damage lung tissue,result in postoperative pulmonary dysfunction,even respiratory failure in severe patients..MiRNA is a kind of small noncoding regulatory RNA,.acted as a regulating role in multiple life process..Studies show miRNA is connected closely with the occurrence、development and outcome of all sorts of lung diseases..With the maturity and popularity of laparoscopic technique,.lung injury after laparoscopic surgery becomes highlighted increasingly..Thus a better exploration and understanding of its mechanism and the role miRNA plays can be helpful to the clinical diagnosis and treatment. This article will make a review of the mechanism of lung injury after laparoscopic surgery as well as the potential role miRNA plays in it.