首页 | 本学科首页   官方微博 | 高级检索  
     


Chromosomal aberrations and micronucleus frequency in nurses occupationally exposed to cytotoxic drugs
Authors:Anwar, Wagida A.   Salama, Somaia I.   Serafy, Mostafa M.EI   Hemida, Samia A.   Hafez, Ahmed S.
Affiliation:1Department of Community, Environmental and Occupational Medicine, Faculty of Medicine, Ain Shams University Cairo 2Community Research Department, National Research Center Cairo 3Intenal Medicine and Medical Oncology Department National Cancer Institute Cairo, Egypt
Abstract:In this study, we evaluated the effect of low level occupationalexposure of nurses in a medical oncology unit in Cairo, Egypt,to anticancer drugs. Twenty nurses who constantly handled thesedrugs and 20 controls, matched according to age and sex, wereexamined. Metaphase chromosomes were studied. Percentages ofmetaphases with chromosomal aberrations were significantly higher(P < 0.001) in the exposed group (6.1 ± 2.7) versusthe controls (2.6 ± 1.6). The detected chromosomal aberrationswere in the form of chromatid gaps, chromatid breaks and acentricfragments. Micronucleated peripheral blood lymphocytes werealso analyzed in cytochalasin B treated binucleated lymphocytes.There was significant increase in cells with micronuclei (P< 0.001) in nurses (10.05 ± 4.71) in comparison tothe matched control (5.42 ± 2.22) (P < 0.001). Nursesexposed to the cytotoxic drugs for
Keywords:
本文献已被 Oxford 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号