| 前列腺素E_1和花生四烯酸对猪缺氧性肺动脉增压反应的影响 |
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| 引用本文： | 赫莉珊,孙秉庸,裴震,杨昌礼,夏亚利,高钰琪. 前列腺素E_1和花生四烯酸对猪缺氧性肺动脉增压反应的影响[J]. 中国病理生理杂志, 1986, 0(2) |
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| 作者姓名： | 赫莉珊 孙秉庸 裴震 杨昌礼 夏亚利 高钰琪 |
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| 作者单位： | 第三军医大学病理生理教研室，第三军医大学高原医学研究室 |
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| 摘 要： | 为探讨前列腺素(PG)在缺氧性肺动脉增压反应(HPPR)中的作用,作者在模拟4000米高原将PGE_1和花生四烯酸(AA)经心导管注入猪的腔静脉:PGE_1明显降低了肺动脉平均压(Ppa),肺血管阻力(PVR)、体循环动脉平均压(Psa)和体循环血管阻力(SVR);AA则增强了HPPR,降低了Psa和SVR。上述结果提示:PGE_1对猪的肺循环和体循环具明显的降压效应;注入AA时猪体循环血管可能合成了舒张血管性PG(VDPG),肺血管主要合成了收缩血管性PG(VCPG),破坏了肺血管中VCPG与VDPG的作用平衡,可能为HPPR增强的原因之一。
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| 关 键 词： | 缺氧症 前列腺素E类 花生四烯酸类 |
The effects of PGE_1 and arachidonic acid on hypoxic pulmonary pressor response in young pig |
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| He Li-Shan,et al. The effects of PGE_1 and arachidonic acid on hypoxic pulmonary pressor response in young pig[J]. Chinese Journal of Pathophysiology, 1986, 0(2) |
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| Authors: | He Li-Shan et al |
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| Affiliation: | He Li-Shan,et al Department of Pathophysiology and Institute of High Altitude Medicine,Third Military Medical College,Chongqing |
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| Abstract: | The effects of PGE 1 and AA on hypoxic puImonary pressor response were studied in anesthetized young pig during hypobaric hypoxia simulating 4000 M altitude. After PGE1 injection, Ppa, PVR, Psa and SVR lowered immediately. AA injection enhanced HPPR but diminished Psa and SVR. The results obtained indicated that after AA injection, vasoconstriction PG (VCPG)was produced in pulmonary blood vessels, while vasodilation PG (VDPG)was produced in systemic blood vessels. It seemed that the effect of VCPG was more obvious than that of VDPG on pulmonary vasculature, thus, HPPR was enhanced by the former. |
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| Keywords: | Anoxia Prostaglandins E Arachidonic acids |
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