多西他赛所致不良反应报告分析

目的:分析某院多西他赛所致不良反应(adverse drug reaction, ADR)的特点及临床表现,总结ADR发生时的处理措施,为临床安全有效的使用多西他赛提供依据.方法:对某院2007-2013年上报的多西他赛所致ADR进行回顾性分析.结果:某院发生多西他赛所致ADR的患者主要为中老年人(年龄≥45岁).原患疾病以肺癌(32.26%)、乳腺癌(27.42%)及妇科肿瘤(24.19%)为主,因此女性患者较多.临床表现以过敏反应、消化系统反应及骨髓抑制居多.结论:使用多西他赛前,医护人员可以根据患者病情采取一定的预防措施;使用后,一旦发生ADR,需根据ADR的类型,及时有效的处理,只有这样才能更好地保证患者的用药安全.

Analysis on adverse drug reactions induced by docetaxel

OBJECTIVE To promote the rational use of docetaxel, the characteristics of adverse drug reactions (ADR) induced by docetaxel and clinical symptoms were analyzed to provide references for docetaxel administration.METHODS A retrospective analysis was performed according to ADR report forms collected from 2007 to 2013.RESULTS The probability of ADR occurrence was the highest in patients ≥45 years. In all ADR cases, the diseases of patients were mainly focused on lung cancer (32.26%), mammary cancer (27.42%) and gynecological oncology (24.19%). Thus, most of the patients were female. The most common clinical symptoms for ADR were anaphylactic reaction, gastrointestinal toxicity and bone marrow depression.CONCLUSION Preventive measures should be adopted according to the patients' conditions before using docetaxel. Once ADR occurs, effective treatments must be performed immediately based on ADR type to ensure the drug safety for patients.