血清铁蛋自在非酒精性脂肪性肝病中的临床意义

目的探讨血清铁蛋白（sF）水平在成人非酒精性脂肪性肝病（NAFLD）患者中的临床意义。方法对入选的158例健康体检人群，进行血清铁蛋白、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL—C）、低密度脂蛋白（LDL—C）、空腹血糖（FBG）、血尿酸（UA）、谷草转氨酶（AST）及谷丙转氨酶（ALT）等各指标检测及肝脏超声检查，根据肝脏超声结果分为NAFLD组（68例）及正常对照组（90例），比较两组间血清铁蛋白水平及血脂、血糖、尿酸、转氨酶等生化指标情况。结果NAFLD组中血清铁蛋白水平及甘油三酯、尿酸、转氨酶明显高于对照组，而高密度脂蛋白明显低于对照组（p〈0．01）；进一步相关性分析显示．血清铁蛋白与谷草转氨酶及谷丙转氨酶显著相关（r=0．260、0．299，P〈0．01）。结论血清铁蛋白水平的升高可能提示NAFLD患者肝损的一个有效指标，并在NAFLD的进展过程中可能起一定的作用。

Clinical Significance of Serum Ferritin in Patients with Nonalcoholic Fatty Liver Disease

Objective To investigate the clinical significance of serum ferritin（SF） in patients with nonalcoholic fatty liver disease （NAFLD）. Methods A total of 158 cases taken the physical examinations were divided into NAFLD group and control group according to the liver B ultrasonography results. Serum ferritin （SF）, total cholesterol （TC）, triglycerides （TG）, high density lipoprotein （HDL-C）, low den- sity lipoprotein （LDL-C）, fasting blood glucose （FBG）, uric acid （UA）, aspartate aminotransferase （AST） and alanine aminotransferase （ALT） were compared in two groups. Results SF, TG, UA, AST and ALT were significantly higher in NAFLD group than those in control group, but HDL-C was lower than that in control group （P〈0.01）. In NAFLD group, SF was positively correlated with AST and ALT （r = 0.260, 0.299, P 〈0.01）. Conclusion The high levels of SF may be a sensitive indicator involved in early injury of fatty liver and play a certain role in the process of NAFLD.