帕金森病患者的抑郁情绪及相关因素研究

目的 :探讨帕金森病 (PD)伴发抑郁的特点及其相关因素。方法 :对 6 0例PD患者进行汉密尔顿抑郁量表(HamiltonDepressionScale ,HAMD)评分 ,并同时进行PD运动功能量表评分 (MDRSPD)。 结果 :PD抑郁的发生率为 4 8.3% ,其中轻度抑郁占 4 0 % ,重度抑郁占 8.3%。其抑郁情绪主要表现为焦虑 /躯体化、阻滞、绝望及睡眠障碍等 ;僵直型PD、震颤—僵直型PD患者绝望感、阻滞及睡眠障碍因子分明显高于震颤型PD ;抑郁程度与年龄、性别、受教育程度无相关关系 ,而与病程、临床功能障碍程度有关。结论 :PD患者中抑郁发生率较高 ,不同的临床类型PD有其抑郁特点 ,僵直型PD患者更易出现抑郁。其抑郁程度与PD患者病程、临床功能障碍程度密切相关。

Depression in Patients with Parkinson''''s Disease

Objective:To investigate the feature of depression in patients with Parkinson's disease(PD) and the related factors.Methods:Use Hamilton Depression Scale(HAMD) to measure the level of depression of 60 patients with PD.Functional state of the patients was evaluated by Motor Dysfunction Rating Scale for Parkinson's Disease(MDRSPD).Results:29 cases(48.3%) were identified to have depression,among whom 40% were of minor or moderate degree,8.3% were severe.The main manifestations of depression were anxiety/body,retardation,hopelessness and insomnia.Scores of hopelessness,retardation,and insomnia factor were significantly higher in the rigidity and tremor combining rigidity patients than those in tremor patients.The level of depression positively correlated with the duration of disease and degree of dysfunction due to PD,and it has no relation with age,sex,and education.Conclusions:The incidence of depression was higher in patients with PD.PD patients of different clinical types had different characteristics of depression.The rigidity type is more likely to get depression.The degrees are closely related to duration of disease and degree of dysfunetion.