乙醇与口腔癌临床流行病学的研究进展

口腔癌是人类最常见的恶性肿瘤之一,其中2/3的患者来自发展中国家.虽然治疗方法在进步,但口腔癌的预后较差,5年生存率仍低于50%.研究口腔癌的危险因素十分重要,明确危险因素可制定有效的预防措施,以减少口腔癌的发生.乙醇是导致口腔癌的危险因素之一,流行病学调查提示乙醇可导致口腔癌,但此结论在动物试验中尚未被证实.研究乙醇因素与口腔癌的关系需要同时分析饮酒量、酒的类型、饮酒习惯以及乙醇对不同性别的影响和烟酒的联合作用.饮酒和吸烟与口腔癌的发生密切相关,但同时吸烟和饮酒者因乙醇致癌的具体机制难以明确,然而戒除烟酒却是获得口腔癌有效预防的关键因素.

Clinical and epidemiological study of alcohol and oral cancer

Oral cancer is one of the most common cancers in human beings,with two-thirds of the cases occur-ring in the developing countries. Developments in the treatment have made great progress,but the relatively sur-vival rate of oral cancer patients is low,and the 5 years survival rate is less than 50%. Studying the risk factors of oral cancer is very important,and the risk factors must be found for primary prevention to decrease the inci-dence of oral cancer. Alcohol is one of the main risk factors for oral canc...