胸腺瘤伴随的消化系统异常

目的探讨胸腺瘤中消化系统异常的发生率及可能的发生机制。方法结合文献，对北京协和医院1985年1月至2002年6月138例胸腺瘤的临床资料进行回顾性分析。结果138例胸腺瘤患者中消化系统症状总发生率12．3％（17／138），其中以慢性腹泻最多（7．2％，10／138），大多数腹泻原因不明确。胸腺瘤患者具有突出的自身免疫倾向，可检测到多种自身抗体；10例慢性腹泻患者中7例检测出自身抗体。胸腺瘤切除后有6例慢性腹泻症状基本缓解。结论胸腺瘤伴随消化系统异常比较常见，其中原因不明的慢性腹泻最多。胸腺瘤患者具有突出的自身免疫倾向，推测自身免疫性肠病可能是此类慢性腹泻的主要病因之一。

Gastrointestinal Disorders Associated with Thymomas

Objective To investigate the characteristics and the incidence of gastrointestinal disorders occurring in patients with thymoma.Methods The medical records of all 138 patients diagnosed as thymoma in PUMC hospital from 1985 to 2002 were analyzed retrospectively.Results 12.3%(17/138)of 138 patients show noteable gastrointestinal symptoms.The most frequent disorder is chronic diarrhea(7.2%,10/138),and the causes of most cases of diarrhea were unclear.Many kinds of autoantibodies were detected in this group of patients,and 7 of the 10 patients with chronic diarrhea showed positive tests for various autoantibodies.The symptoms of 6 cases of chronic diarrhea were almost relieved after thymomas was resected.Conclusion Gastrointestinal disorders are relatively common in patients with thymoma.Chronic diarrhea associated with thymoma is the most frequent disorder found in such patients.This group of patients has remarkable predisposition to autoimmunity and the diagnosis of autoimmune enteropathy should be considered in such cases.