柴胡桂枝汤治疗抑郁症临床观察

目的：观察柴胡桂枝汤与盐酸帕罗西汀联合治疗抑郁症的疗效及不良反应。方法：70例确诊为抑郁症的患者,采用随机数字表法分成试验组和对照组,各35例。对照组口服盐酸帕罗西汀片20mg,1次/d;试验组在对照组药物的基础上加服柴胡桂枝汤颗粒,冲服,2次/d,早晚分服。疗效及不良反应用汉密顿抑郁量表及副反应观察量表分别观察。对照组与试验组疗程均为6周。结果：治疗6周后两组HAMD评分均比治疗前明显下降（P〈0.05）,试验组下降更明显（P〈0.05）;试验组不良反应小,仅2例出现口干,对照组有13例不同程度的出现了口干、多汗、困倦和视物模糊等不良反应。表明柴胡桂枝汤合并盐酸帕罗西汀改善抑郁症的疗效更显著,且柴胡桂枝汤能明显减少盐酸帕罗西汀的副作用。结论：柴胡桂枝汤联合盐酸帕罗西汀治疗抑郁症可明显改善临床症状,且降低盐酸帕罗西汀的副作用,增加了患者的耐受性和治疗依从性。

Clinical observation on treating depression with the Chaihu Guizhi decoction

Objective： To observe clinical effects and side effects of the Chaihu Guizhi decoction plus paroxetine hydrochloride on depression. Methods： 70 patients were randomly divided into two groups, 35 cases for each. The control group was given paroxetine hydrochloride, once everyday; another was given the Chaihu Guizhi decoction more, twice everyday, 6 weeks for 1 course. Clinical effects and side effects were analyzed by HAMD table and side effects table. Results： With 6 weeks’ treatment, HAMD scores in two groups were significantly lower than before （P〈0.05）, especially in the treatment group （P〈0.05）; there were fewer side effects in the treatment group, 2 cases in the treatment group, but 13 cases in the control group, such as dry mouth, sweating, drowsiness and blurred vision and so on. All above suggests that the efficacy of the Chaihu Guizhi decoction plus paroxetine hydrochloride on depression is significant, and the Chaihu Guizhi decoction can reduce side effects of paroxetine hydrochloride. Conclusion： The Chaihu Guizhi decoction plus paroxetine hydrochloride on depression could significantly improve clinical symptom and reduce side effects of paroxetine hydrochloride, and increase the patients’ tolerance and compliance.