肾移植术后恶性肿瘤的临床分析

目的总结分析肾移植术后恶性肿瘤的发病率、临床特点及治疗效果。方法回顾分析1992年1月至2008年1月山西省第二人民医院肾移植透析中心825例肾移植受者术后恶性肿瘤的发生率、临床特点、免疫抑制剂调整及预后情况。结果 825例肾移植受者中有27例发生恶性肿瘤,发病率为3.3%,其中男性12例,女性15例。泌尿系肿瘤11例,占恶性肿瘤的40.7%;消化系统肿瘤6例,占恶性肿瘤的22.2%;乳腺癌2例,占恶性肿瘤的7.4%;皮肤癌3例,占恶性肿瘤的11.1%;肺癌2例,占恶性肿瘤的7.4%;卵巢癌、骨转移癌、颅内肿瘤各1例,分别占恶性肿瘤的3.7%。发现肿瘤时5例有远处转移,诊断肿瘤时26例移植肾功能正常,1例移植肾失功恢复血液透析。27例患者均及时调整免疫抑制剂剂量辅以化疗或放疗,18例行手术治疗,死亡9例,病死率为33.3%。结论肾移植术后恶性肿瘤发病率明显高于普通人群,泌尿系肿瘤的发病率位居第一,该现象与肾移植受者长期应用免疫抑制剂密切相关。

The clinical research of malignant tumor after renal transplantation

Objective To analysis the incidence of malignant tumor,clinical characteristics and treatment effect of malignant tumor after renal transplantation.Methods It was retrospectively analyzed the incidence of malignant tumor after renal transplantation,clinical characteristics,immunosuppressants adjustment and prognosis of 827 patients from March 1992 to March 2008 in the sencond people hospital of Shanxi.Results Twenty-seven patients had malignant tumor among 825 patients in renal transplant recipients,the inc...