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| 寻常型银屑病患者外周血CD4~+CD25~+及CD8~+CD25~+细胞的检测 | |
| 引用本文： | 张艳杰,张士发,王莉丽,王良民.寻常型银屑病患者外周血CD4~+CD25~+及CD8~+CD25~+细胞的检测[J].实用皮肤病学杂志,2011,4(2):72-74. |
| 作者姓名： | 张艳杰 张士发 王莉丽 王良民 |
| 作者单位： | 1. 深圳市宝安区松岗人民医院皮肤科,518105 2. 沈阳军区总医院皮肤科 3. 辽宁医学院附属医院皮肤科 |
| 摘 要： | 目的研究进展期寻常型银屑病患者外周血CD4+CD25+和CD8+CD25+调节性T细胞的数量变化及其在银屑病免疫病理学发病机制中的作用。方法应用流式细胞术对进展期寻常型银屑病患者外周血CD4+CD25+和CD8+CD25+调节性T细胞进行检测。结果进展期寻常型银屑病外周血CD4+CD25+细胞及CD8+CD25+调节性T细胞数量与正常对照组相比,均显著降低(P<0.05,P<0.005),而CD4+CD25+/CD8+CD25+比值无显著性差异(P>0.05)。结论寻常型银屑病的发病与CD4+CD25+和CD8+CD25+调节性T细胞的同步降低有关,与二者的比值无关。 |
| 关 键 词： | 寻常型银屑病 CD4+CD25+调节性T细胞 CD8+CD25+调节性T细胞 |
Detection of CD4+CD25+ and CD8+CD25+ regulatory T cells in peripheral blood from patients with psoriasis vulgaris |
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| ZHANG Yan-jie,ZHANG Shi-fa,WANG Li-li,et al.Detection of CD4+CD25+ and CD8+CD25+ regulatory T cells in peripheral blood from patients with psoriasis vulgaris[J].Journal of Practical Dermatology,2011,4(2):72-74. | |
| Authors: | ZHANG Yan-jie ZHANG Shi-fa WANG Li-li |
| Institution: | ZHANG Yan-jie,ZHANG Shi-fa,WANG Li-li,et al Department of Dermatology,Baoan District Songgang People's Hospital,Shenzhen 518105,China |
| Abstract: | Objective To investigate the quantity of CD4+CD25+ and CD8+CD25+ regulatory T cells in peripheral blood and evaluate its role in the immunopathological pathogenesis in patients with psoriasis vulgaris.Metholds The quantity of CD4+ CD25+ and CD8+ CD25 regulatory T cells in peripheral blood from patients with progressive stage psoriasis vulgaris were accounted by flow cytometry.Results The quantity of CD4+CD25+ and CD8+CD25+ regulatory T cells in psoriasis vulgaris was significantly lower than that in normal ... |
| Keywords: | Psoriasis vulgaris CD4 CD25 rgulatory T cells CD8 CD25 rgulatory T cells |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |