抗菌功能性敷料联合糠酸莫米松乳膏治疗小儿湿疹的疗效观察

目的探讨抗菌功能性敷料联合糠酸莫米松乳膏治疗小儿湿疹的临床疗效。方法选取北京市海淀医院2016年1月—2017年7月接受治疗的92例小儿湿疹患者为研究对象,随机分为对照组和治疗组,每组各46例,对照组患儿涂抹糠酸莫米松乳膏,0.1 mg/次,每晚1次。治疗组患儿在对照组的基础上外敷抗菌功能性敷料,0.1 mg/次,1~3次/d。两组患者均连续治疗14 d。治疗后,观察两组的临床疗效,比较两组治疗前后临床症状、皮损程度评分和不良反应及复发情况。结果治疗后,对照组和治疗组的总有效率分别为84.78%、97.83%,两组总有效率比较差异有统计学意义(P0.05)。治疗后,两组临床症状和皮损程度评分均显著降低,同组治疗前后差异有统计学意义(P0.05);治疗后治疗组临床症状和皮损程度评分均显著低于对照组,两组比较差异有统计学意义(P0.05)。对照组和治疗组的复发率分别为19.57%、4.35%,两组复发率比较差异具有统计学意义(P0.05)。结论抗菌功能性敷料联合糠酸莫米松乳膏治疗小儿湿疹疗效显著,可明显改善患儿临床症状,安全性较高,具有一定的临床推广应用价值。

Clinical observation of antimicrobial functional dressing combined with Mometasone Furoate Cream in treatment of infantile eczema

Objective To investigate the clinical effect of antimicrobial functional dressing combined with Mometasone Furoate Cream in treatment of infantile eczema. Methods Patients (92 cases) with infantile eczema in Beijing Haidian Hospital from January 2016 to July 2017 were randomly divided into control and treatment groups. Each group had 46 cases. Patients in the control group were given Mometasone Furoate Cream, 0.1 mg/time, once every night. Patients in the treatment group were given antimicrobial functional dressing, 0.1 mg/time, 1-3 times/d. All patients were continuously treated for 14 d. After treatment, the clinical efficacy was evaluated, and the clinical symptoms and skin lesions score, adverse reaction, and recurrence in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 84.78% and 97.83%, respectively, and there was difference between two groups (P<0.05). After treatment, clinical symptoms and skin lesions score in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, clinical symptoms and skin lesions score in the treatment group were lower than those in the control group, and there was difference between two groups (P<0.05). The recurrence rate in the control and treatment groups were 19.57% and 4.35%, respectively, and there was difference between two groups (P<0.05). Conclusion Antimicrobial functional dressing combined with Mometasone Furoate Cream has a significant effect in treatment of infantile eczema, and can significantly improve the clinical symptoms with good safety, which has a certain clinical application value.