2013-2016年西安交通大学第一附属医院麻醉性镇痛药应用分析

目的 对西安交通大学第一附属医院麻醉性镇痛药的临床应用情况及用药趋势进行分析,为麻醉性镇痛药的规范化管理和临床合理用药提供参考.方法 采用回顾性分析方法,调取西安交通大学第一附属医院2013—2016年麻醉性镇痛药的用药数据,对用药总量、销售金额、用药频度(DDDs)、限定日费用(DDC)和排序比(B/A)等进行统计分析.结果 麻醉性镇痛药的总销售金额呈逐年递增趋势.枸橼酸芬太尼注射液、注射用盐酸瑞芬太尼与芬太尼透皮贴剂在各年度DDDs均居于前几位.2013—2016年各药品的DDC值基本稳定不变,缓释剂型的DDC普遍高于普通剂型.盐酸羟考酮缓释片(10 mg)和注射用盐酸瑞芬太尼的B/A较小,而枸橼酸芬太尼注射液(0.1 mg)的B/A偏高.结论 西安交通大学第一附属医院麻醉性镇痛药应用基本合理,基本符合《癌症三阶梯止痛指导原则》.

Analysis on application of narcotic analgesic drugs in the First Affiliated Hospital of Xi'an Jiaotong University from 2013 to 2016

Objective To analyze the application and tendency of narcotic analgesic drugs in the First Affiliated Hospital of Xi''an Jiaotong University, so as to provide reference for standard management and clinical rational use of drugs. Methods A retrospective study was conducted. The data of utilization of narcotic analgesic drugs in the First Affiliated Hospital of Xi''an Jiaotong University from 2013 to 2016 were collected and analyzed statistically, and amounts, consumption sums, frequency of drug use (DDDs), defined daily cost (DDC), and drug sequence ratio (B/A) were calculated and analyzed. Results Total consumption sums of narcotic analgesic drugs increased year by year. DDDs of Fentanyl Citrate Injection, Remifentanil Hydrochloride for Injection, and Fentanyl Transdermal Patches in every year ranked the forefront. DDC of narcotic analgesic drugs was basically stable from 2013 to 2016. DDC of slow release formulation was higher than ordinary dosage forms. B/A of Oxycodone Hydrochloride Prolonged-release Tablets (10 mg) and Remifentanil Hydrochloride for injection were low, but B/A of Fentanyl Citrate Injection (0.1 mg) was high. Conclusion The utilization of narcotic analgesic drugs is rational in the First Affiliated Hospital of Xi''an Jiaotong University on the whole, which is in line with the "Three Ladder Analgesic Treatment Programs of Cancer Pain".