中医药对糖尿病肾病肾功能不全代偿期生存质量影响的研究

目的 寻求能够改善糖尿病肾病肾功能不全患者生存质量的有效治疗方案.方法 将161例糖尿病肾病肾功能不全代偿期患者随机分为中医辨证组(A组)54例、氯沙坦组(B组)55例、中医辨证结合氯沙坦组(C组)52例.A组分别予止消通脉宁颗粒剂、止消温肾宁颗粒剂、止消保肾宁颗粒剂及西药安慰剂;B组予氯沙坦及不同的中药安慰剂;C组予中医辨证治疗结合氯沙坦治疗.观察3组治疗对患者肾功能和生存质量的影响.结果 在降低肾功能指标方面A组优于B组,C组居中;3组治疗均可显著提高患者生存质量.结论 建立在西医学降糖、降压基础治疗上的中医辨证论治方案能够较好地改善糖尿病肾病肾功能不全患者的肾功能指标,并能提高患者的生存质量.

Influence of Chinese medicine on survival quality in patients with renal insufficiency due to diabetic nephropathy in compensatory phase

Objective To find out an effective therapeutic plan for promoting the survival quality in the patients with renal insufficiency due to diabetic nephropathy in compensatory phase. Method All 161 patients with renal insufficiency due to diabetic nephropathy in compensatory phase were randomly divided into the TCM syndrome differentiation group (A group, n=54), Losartan group (B group, n=55) and TCM syndrome differentiation combined Losartan group (C group, n=50). A group was treated with Zhixiaotongmaining Granules, Zhixiaowenshenning Granules, Zhixiaobaoshenning Granules and the dummy of Western medicine. B group was treated with Losartan and different dummies of Chinese medicine. C group was treated according to TCM syndrome differentiation combined Losartan. The influences of above three therapeutic plans on renal function and survival quality in the patients of three groups were observed. Result In the improvement of renal function indexes the outcomes of A group were better than those of B group. C group had a medial result. The survival qualities of the patients in three groups were all promoted obviously. Conclusion The therapeutic plan of TCM syndrome differentiation, which is established on the base of hypoglycemic and depressor treatment of modern medicine, can improve the renal function indexes and promote the survival quality in the patients with renal insufficiency due to diabetic nephropathy.