Prevention and treatment of radiation-induced lung injury by hydroxypiperquin phosphate: a clinical and experimental study

While total body irradiation is widely used inpreconditioning for hematopoietic stem cell transplantation (HSCT), radiation-induced lung injury hasbecome one of the major reasons of transplantation-associated death. Khatibll] reported that the incidence of radiation-induced pneumonitis is 50% in 245patients who were irradiated with 9. IGy in HSCT. Asradiotherapy be used in the treatment of chest tumormore frequently, the tumor is controlled, hut the radiation-induced lung fibrosis can hard…

Prevention and treatment of radiation-induced lung injury by hydroxypiperquin phosphate: a clinical and experimental study

Objective: To evaluate the hydroxypiperquin phosphate (HPQP) as a modifier of radiation-induced injury in human and rat lungs. Methods: Sixty-five patients with lung cancer treated with conventional radiotherapy were divided into 2 groups randomly: Thirty cases were treated with HPQP and the others were in a control group. The changes of X - ray manifestation before, after and during taking drug were compared. An animal model of radiation-induced fibrosis of lungs was also established. Hydroxyproling (HP) content in lung tissue and the pathological changes in rat lungs were checked with microscope and electron microscope after 4 months and 6 months respectively. Results: The changes of lung X-ray manifestation in treatment group were much lighter than that in control group. The HP content and the change of pathology in the lungs of those rats with HPQP treatment were obviously less than that in control group. Conclusion: HPQP plays an important role in prevention and treatment of radiation-induced injury in lungs.