| Abstract: | Objective: To observe the distribution pattern of genetic polymorphisms of gene variable number tandem repeat (VNTR) in the deleted gene in colorectal cancer (DCC) on Shaanxi people, and discuss the possible association between it and the susceptibility of esophageal cancer. Methods: Polymorphisms of DCC gene VNTR was studied with PCR in blood samples of 56 unrelated individuals and 49 esophageal cancer samples and 34 pericancerous samples in Shaanxi people. Results: There were 11 alleies wing from 167 bp to 210 bp in all subjects. The range of allele frequencies was from 0.009 to 0. 188, and allele A3, A4, A7 and A9 were more frequent in the control. The polymorphism information content(PIC) of DCC gene VNTR was 0.879,the heterozygosity(H) was 73.2% in the control. The allele frequency of DCC gene VNTR polymorphism in esophageal cancer was significantly different from that of control(P < 0. 01 ). Conclusion: Our findings suggest that polymorphism of DCC gene VNTR might be associated with the susceptibility of esophageal cancer. |
