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Emergence of genetically linked vaccine-originated poliovirus type 2 in the absence of oral polio vaccine,Jerusalem, April to July 2022 |
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| Authors: | Neta S Zuckerman Itay Bar-Or Danit Sofer Efrat Bucris Hagar Morad Lester M Shulman Nofar Levi Leah Weiss Irina Aguvaev Zvi Cohen Klil Kestin Rinat Vasserman Michal Elul Ilana S Fratty Miranda Geva Marina Wax Oran Erster Ruth Yishai Lior Hecht-Sagie Sharon Alroy-Preis Ella Mendelson Merav Weil |
| Affiliation: | 1.Central Virology Laboratory, Public Health Services, Ministry of Health, Chaim Sheba Medical Center, Ramat Gan, Israel; 2.School of Public Health, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; 3.The Israel Center for Disease Control, Israel Ministry of Health, Ramat-Gan, Israel; 4.Department of Laboratories, Public Health Services, Ministry of Health, Jerusalem, Israel; 5.Public Health Services, Ministry of Health, Jerusalem, Israel |
| Abstract: | We report an emergence and increase in poliovirus type 2 detection via routine wastewater surveillance in three non-overlapping regions in the Jerusalem region, Israel, between April and July 2022. Sequencing showed genetic linkage among isolates and accumulation of mutations over time, with two isolates defined as vaccine-derived polioviruses (VDPV). This demonstrates the emergence and potential circulation of type 2 VDPV in a high-income country with high vaccine coverage and underscores the importance of routine wastewater surveillance during the polio eradication. |
| Keywords: | Vaccine Derived Polio Virus (VDPV) Polio type 2 (PV2) Environmental surveillance Whole Genome Sequencing (WGS) |