Angioimmunoblastic T-cell Lymphoma Presenting as a Methotrexate-associated Lymphoproliferative Disorder with Extreme Peripheral Blood Plasmacytosis |
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| Authors: | Hiroyuki Murakami Masanori Makita Tatsunori Ishikawa Takanori Yoshioka Keina Nagakita Yoko Shinno Tadashi Yoshino Yoshinobu Maeda Kazutaka Sunami |
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| Affiliation: | 1.Department of Hematology, National Hospital Organization Okayama Medical Center, Japan; 2.Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan; 3.Department of Pathology, National Hospital Organization Okayama Medical Center, Japan; 4.Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan |
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| Abstract: | A 74-year-old man was admitted to our hospital because of systemic lymphadenopathy, weight loss, and a fever at night that had persisted for approximately 1 month. Blood tests revealed extreme peripheral blood plasmacytosis and hypergammaglobulinemia. A lymph node biopsy showed angioimmunoblastic T-cell lymphoma (AITL). Based on the history of methotrexate (MTX) administration, the established diagnosis was MTX-associated lymphoproliferative disorder (MTX-LPD). After MTX was discontinued, the lymphadenopathy spontaneously regressed and the plasmacytosis disappeared. He had no disease progression for three years. We found that AITL as an MTX-LPD can cause plasmacytosis, and the prognosis of this disease may not be poor. |
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| Keywords: | methotrexate angioimmunoblastic T-cell lymphoma MTX-associated lymphoproliferative disorder plasmacytosis |
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