| 银杏外种皮中银杏酸的体外抗肿瘤活性研究 |
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| 引用本文： | 杨小明,钱之玉,陈钧,朱伟,谢吉民.银杏外种皮中银杏酸的体外抗肿瘤活性研究[J].中药材,2004,27(1):40-42. |
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| 作者姓名： | 杨小明 钱之玉 陈钧 朱伟 谢吉民 |
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| 作者单位： | 1. 江苏大学,江苏,镇江,212013
2. 中国药科大学药理教研室,南京,210009 |
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| 基金项目： | 江苏省教育厅自然科学基金 |
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| 摘 要： | 目的:探讨银杏酸对肿瘤细胞和正常细胞生长的影响.方法:从银杏外种皮中制备纯度90%的银杏酸同系混合物.采用MTT法,检测银杏酸对各细胞株生长的抑制作用.结果:银杏酸浓度为5.0μg/ml时,对肿瘤细胞生长都有明显的抑制作用,其中对肺癌LTEP-a-2细胞抑制率达到59.1%,而对正常细胞无影响;高浓度银杏酸对正常细胞和肿瘤细胞生长的抑制作用趋于一致.结论:银杏酸对体外培养的肿瘤细胞有较强抑制作用,浓度低于5.0μg/ml时对正常细胞生长无影响.
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| 关 键 词： | 银杏酸 肿瘤细胞 |
| 修稿时间： | 2003年8月19日 |
Study on Antitumor Activities of Ginkgolic Acids from Ginkgo Sarcotestas in Vitro |
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| Yang Xiaoming,Qian Zhiyu,Chen Jun,Zhu Wei,Xie Jimin.Study on Antitumor Activities of Ginkgolic Acids from Ginkgo Sarcotestas in Vitro[J].Jorunal of Chinese Medicinal Materials,2004,27(1):40-42. |
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| Authors: | Yang Xiaoming Qian Zhiyu Chen Jun Zhu Wei Xie Jimin |
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| Institution: | Jiangsu University, Zhenjiang 212013. |
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| Abstract: | OBJECTIVE: To study the influence of ginkgolic acids on human tumor cells and normal cells. METHODS: Ginkgolic acids (total concentration 90%) was prepared from ginkgo sarcotestas. The inhibitive effect of ginkgolic acids on human tumor cells and normal cells lines was examined by MTT assay. RESULTS: When the concentration was 5.0 micrograms/ml, ginkgolic acids obviously inhibited the growth of tumor cells and didn't influence the normal cells. Inhibitive rate of ginkgolic acids on LTEP-a-2 was 59.1%. High-concentration ginkgolic acids had inhibitive effect on the growth of tumor cells and normal cells. CONCLUSION: Ginkgolic acids had a obvious inhibitive effect on tumor cells in vitro. When the concentration was under 5.0 micrograms/ml, ginkgolic acids didn't influence the growth of normal cells. |
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| Keywords: | MTT |
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