| Abstract: | The pharmacological properties of 4 derivatives of 11-desoxy-prostaglandins E (uterotonic, luteolytic, hypotensive, anti-inflammatory, diarrhogenic ones and also acute toxicity) were studied. Compound I possessed the uterotonic activity which decreased with an alpha-chain elongation and a radical introduction into a benzene ring. Compounds I and II exhibited the luteotropic properties at low doses and the luteolytic ones at high doses. The compounds under study had the hypotensive activity due to the presence of a benzene ring in a W-chain. |
