不同剂量的右美托咪定对减少全身麻醉苏醒期躁动的效果观察

目的 探讨不同剂量右美托咪定对减少全身麻醉苏醒期躁动的效果.方法 选择48例全身麻醉术后苏醒期躁动的患者,随机分为A、B、C组（各16例）,采用不同剂量右美托咪定（0.3、0.5、1.0 μg/kg）治疗,观察治疗后不同时间点血压、心率、Riker镇静-躁动（SAS）评分等变化,并比较恢复室滞留时间.结果 B、C两组在给药后即刻、给药后5 min和给药后10 min的SAS评分均显著低于A组（P均＜0.05）.C组给药后即刻、给药后5min的收缩压和心率均显著降低,低于B组和A组（P均＜0.05）;B组仅给药后即刻的心率低于A组.3组患者恢复室滞留时间比较,B组（37.5±6.4）min显著低于A组和C组（43.2±8.9）、（47.5±9.8） min,F=14.362、P＜0.001].结论 右美托咪定是较理想的镇静镇痛药物,0.5 μg/kg右美托咪定可减少患者全身麻醉苏醒期躁动和心血管反应,是最佳的治疗剂量.

Dose-effect of dexmedetomidine in reducing restlessness after anesthesia

Objective To investigate the different doses of dexmedetomidine on reducing the effects of restlessness after anesthesia.Methods Forty-eight patients who occurred restlessness after general anesthesia were collected and randomly divided into A,B,C group （16 cases in each group）.Dexmedetomidine were given at dose of 0.3 μg/kg,0.5 μg/kg,1.0 μg/kg for treatment as A,B,C group.Blood pressure,heart rate,Riker sedation-restlessness （SAS） score and other changes of patients were recorded at different time points after treatment.Results SAS scores were significantly lower in B,C groups than that in A group （P ＜ 0.05） at immediately after administration and 5 min and 10 min after administration.Systolic pressure and heart rate were significantly lower in C group than in B,A group （P ＜ 0.05） at immediately after administration and 5 min after administration.Only the heart rate in B group at immediately after administration was lower than that in A group.Time in the recovery room in B group was （37.5 ± 6.4） min,significantly lower than A group and C group （（43.2 ± 8.9） min,（47.5 ± 9.8） min ; F =14.362 ; P ＜ 0.001）.Conclusion Dexmedetomidine is a more ideal sedation drug and 0.5 μg/kg dexmedetomidine can reduce restlessness and cardiovascular reactions in patients with restlessness after general anesthesia,which is the best recommending therapeutic dose.