室间隔缺损介入治疗前后血浆白细胞介素8水平的变化

目的 观察先天性心脏病室间隔缺损（VSD）患儿介入治疗前后血浆白细胞介素8（IL-8）水平以及心腔结构的变化,探讨IL-8水平变化的特点及其与心功能状态的关系.方法 选择我院2011年2月至2013年2月住院接受介入封堵治疗的VSD患儿100例为VSD组,选取同期50名健康儿童作为对照组.分别在术前、术后第7天、术后6个月采用放射免疫法测定IL-8浓度.所有患儿在术前、术后第7天和术后6个月分别进行超声心动图检查,测定左心室舒张末期内径（LVEDD）、左心室收缩末期内径（LVESD）、左心室收缩末期容量（LVESV）、左心室舒张末期容量（LVEDV）、左心室射血分数（LVEF）.分析血浆IL-8水平与LVEDD、LVESD、LVESV、LVEDV、LVEF的相关性.结果 （1）血浆IL-8：术前VSD组（0.64±0.08） pg/L和对照组（0.53 ±0.07） pg/L比较,差异有统计学意义（t=6.61,P＜0.05）;VSD组患儿术前与术后第7天（0.69 ±0.06） pg/L、术后第7天与术后6个月（0.55±0.05）pg/L比较,差异均有统计学意义（t=5.45、t=12.08,P均＜0.05）.术后6个月VSD组与对照组比较差异无统计学意义（t =0.86,P＞0.05）.（2）心腔结构各参考数：VSD组患儿LVEDD、LVESD、LVEDV、LVESV在介入术后第7天[（41.47 ±3.38） mm、（27.17 ±3.76） mm、（76.72±17.03） ml、（26.23±6.13） ml]及术后6个月[（36.21±3.75） mm、（22.49 ±3.04） mm、（65.38±16.22） ml、（22.23±5.71） ml]均较术前[（45.28±3.69） mm、（29.02±3.17） mm、（86.33 ±19.68） ml、（30.12 ±7.06）nl]明显缩小,差异有统计学意义（P均＜0.05）,且术后6个月较术后第7天进一步减小（P均＜0.05）.（3）VSD组血浆IL-8水平与LVEDD、LVESD、LVESV、LVEDV呈显著正相关（r=0.76、0.59、0.66、0.75,P均＜0.05）.结论 VSD患儿血浆IL-8水平在介入封堵术前明显增高,并在术后降低,且与心脏腔径的改善相关,提示心肌血管免疫炎症递质IL-8的过度激活参与并?

Level change of plasma IL-8 before and after interventional therapy on patients with ventricular septal defect

Objective To observe the changes of plasma interleukin-8 （IL-8） and cardiac performance on children with ventricular septal defect （VSD） after interventional therapy in order to investigate the relationship between the cardiac performance and IL-8.Methods A total of 100 children with VSD for cardiac catheter occlusion in the 1 st Hospital of Hebei Medical University from Feb.2011 to Feb.2013 were enrolled in this study as the VSD group.The control group included 50 healthy children.Concentrations of plasma IL-8 were measured before and the 7th day and 6th month after cardiac catheterization.Before and the 7th day and 6th month after cardiac catheterization,the parameters of left ventricular end diastolic diameter （LVEDD）,left ventricular end systolic diameter （LVESD）,left ventricular end systolic volume （LVESV）,left ventricular end diastolic volume （LVEDV） and left ventricular ejection fraction （LVEF） were measured by echocardiography.The relationships between plasma IL-8 levels and echocardiographic cardiac functional indexes were analyzed.Results （1） The plasma levels of IL-8 in VSD and control group were （0.64 ± 0.08） pg/L and （0.53 ±0.07） pg/L,and there was significant difference between two groups（t =6.61,P 〈 0.05）.IL-8 levels of VSD children at before operation,the 7th day and 6 month after operation were （0.64 ± 0.08） pg/L,（0.69 ± 0.06） pg/L,（0.55 ± 0.05） pg/L respectively,and the differences were statistically significant （t =5.45,t =12.08,P 〈0.05）.There was no significant difference in terms of IL-8 at the 6 month after operation and before operation.（2） LVEDD,LVESD,LVEDV,LVESV in VSD children at the 7th days after operation were （41.47 ±3.38） mm,（27.17 ±3.76） mm,（76.72 ± 17.03） ml,（26.23 ±6.13） ml respectively,and （36.21 ± 3.75） mm,（22.49 ± 3.04） mm,（65.38 ± 16.22） ml,（22.23 ± 5.71） ml at the 6 months after operation,significant decreased than that before operation（（45.28 ± 3.69） mm,?