血浆同型半胱氨酸水平与轻度认知功能障碍对老年2型糖尿病患者的影响 |
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引用本文: | 周文锐,梁兴伦,朱敏洁,李琛,陆媛.血浆同型半胱氨酸水平与轻度认知功能障碍对老年2型糖尿病患者的影响[J].综合临床医学,2014(11):1169-1172. |
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作者姓名: | 周文锐 梁兴伦 朱敏洁 李琛 陆媛 |
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作者单位: | 上海市杨浦区中心医院老年二科,200090 |
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摘 要: | 目的 分析血浆同型半胱氨酸(Hcy)水平与认知功能障碍对2型糖尿病患者的影响,并探讨影响认知功能的其他因素.方法 2型糖尿病患者80例,根据简易精神状态量表(MMSE)评分将2型糖尿病患者分为认知障碍组(38例)、非认知障碍组(42例),选择健康对照者30名作为正常对照组.测定3组血浆Hcy、糖化血红蛋白、血脂、尿酸、24 h尿微量白蛋白等指标.结果 糖尿病认知障碍组、糖尿病非认知障碍组、正常对照组血浆Hcy浓度分别为(19.56±5.23)、(16.21 ±3.27)、(14.67 ±4.27)μmol/L,3组差异有统计学意义(F=3.76,P<0.05),且糖尿病认知障碍组血浆Hcy水平高于糖尿病非认知障碍组(P<0.05)与正常对照组(P<0.01),糖尿病非认知障碍组高于正常对照组(P<0.05);影响患者认知功能的其他因素包括年龄、糖化血红蛋白、体质量指数、糖尿病病程及血浆Hcy水平,与患者MMSE评分呈负相关(r值分别为-0.336、-0.285、-0.226、-0.392、-0.312,P均<0.05).结论 年龄、糖尿病病程、糖化血红蛋白、体质量指数均可影响患者的认知功能,Hcy水平升高是2型糖尿病患者认知障碍的一个危险因素.
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关 键 词: | 2型糖尿病 同型半胱氨酸 认知障碍 糖尿病脑病 |
Effect of plasma homocysteine levels and mild cognitive dysfunction on elderly type 2 diabetes |
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Authors: | Zhou Wenrui Liang xinglun Zhu minjie Li chen Lu yuan |
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Institution: | (Gerontology Department, Yangpu,Shanghai Tongji University Hospital) |
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Abstract: | Objective To investigate the effect of plasma homocysteine (Hcy) levels and cognitive dysfunction on patients with type 2 diabetes and explore the other factors that affect cognitive function.Methods 80 patients with type 2 diabetes were selected as our subjects and they were divided into cognitive impairment group (38 cases),cognitive normal group (42 cases) according to a simple mental state scale(MMSE) score.The plasma Hcy,glycosylated hemoglobin,blood lipid,uric acid,24 h urine trace albumin were measured.Results Plasma Hcy concentration in diabetic cognitive dysfunction,non cognitive impairment group and normal control group respectively were(19.56 ± 5.23),(16.21 ± 3.27),(14.67 ± 4.27) tmol/L,and there was statistically significant difference(F =3.76,P <0.05).The plasma Hcy levels in diabetic cognitive impairment group was higher than that non-cognitive impairment group(P < 0.05) and normal control group (P < 0.01),The factors impaired cognitive function in patients with other factors included age,glycosylated hemoglobin,body mass index,diabetes duration and plasma Hcy levels,and there were negative correlation with MMSE score (r =-0.336,-0.285,-0.226,-0.392,-0.312 ; all P values were less than 0.05).Conclusion Patient's age,duration of diabetes,glycosylated hemoglobin and BMI can affect cognitive function in patients.Higher Hcy levels in patients with type 2 diabetes is a risk factor for cognitive impairment. |
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Keywords: | Diabetes mellitus Type 2 Homocysteine Cognitive impairment Diabetic encephalopathy |
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