奈达铂与草酸铂腹腔热灌注治疗卵巢癌的效果比较

目的 观察奈达铂和草酸铂在腹腔热灌注治疗卵巢癌的效果和不良反应.方法 选取卵巢癌合并腹腔积液和术后及术后复发的患者57例,随机分为观察组32例和对照组25例.分别应用奈达铂和草酸铂热灌注治疗,即将奈达铂或草酸铂用体腔热灌注机加热到42～ 43℃,以一定速度灌注入腹腔.观察灌注治疗后的效果和不良反应.结果 两组近期效果比较：全部病例随访6个月以上,观察组腹水控制率为90.6％,其中CR 34.4％ （11/32）,PR 56.2％ （18/32）;对照组腹水控制率为68.0％,其中CR 16.0％ （4/25）,PR 52.0％（13/25）,观察组与对照组比较差异有统计学意义（x^2=39.36,P＜0.05）.观察组严重不良反应轻于对照组.结论 奈达铂用于腹腔热灌注治疗卵巢癌较草酸铂具有效果好,不良反应少的优点,可提高患者化疗的依从性和完成化疗周期.

Clinical efficacy of Nedaplatin and oxaliplatin in hyperthermic peritoneal perfusion treatment of patients with malignant ascites

Objective To investigate the effect of Nedaplatin and oxaliplatin in hyperthermic peritoneal perfusion treatment of patients with malignant ascites as well as its adverse chemotherapy effect.Methods Fifty seven ovarian cancer patients of with ascites were randomly divided into the observation group（32 cases） and the control group （25 cases）.Patients were respectively treated with nedaplatin or oxaliplatin for intraperitoneal hyperthermic perfusion.The nedaplatin plus saline 2 000 ml or oxaliplatin plus 5% glucose 2 000 ml were heated with hyperthermic perfusion machine to 42-43℃,and then infusion into abdominal cavity of patients at certain speed.The efficiency and toxicity of the two groups after reperfusion were recorded.Results All patients were followed up for 6 months.The control rate of ascetic fluid in observation group was 90.6%,of which,CR was 34.4% （11/32） and PR 56.2% （18/32）.The control rate of ascetic fluid in control group was 68.0%,of which,CR was16.0% （4/25） and PR was 52.0% （13/25）.The difference between observation and control group was statistically significant in terms of therapy efficacy（x^2 =39.36,P 〈0.05）.The side effect in patients of observation group was slight than that in control group.Conclusion Nedaplatin for intraperitoneal hyperthermic perfusion with oxaliplatin has advantages with good curative effect,low toxicity,which can improve the compliance of chemotherapy in order to complete chemotherapy cycles.