| 中药逆转肿瘤多药耐药的研究进展 |
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| 引用本文： | 程涛,宋霞,马园园,姜远英,曹永兵.中药逆转肿瘤多药耐药的研究进展[J].西北药学杂志,2014(3):324-328. |
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| 作者姓名： | 程涛 宋霞 马园园 姜远英 曹永兵 |
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| 作者单位： | [1]福建中医药大学,福州350108; [2]中国药科大学,南京210009; [3]第二军医大学,上海200433 |
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| 摘 要： | 目的综述逆转肿瘤多药耐药(MDR)的研究进展。方法检索中药提取物或中药单体联合化疗药物逆转肿瘤MDR的研究。结果一些中药提取物或中药单体能使耐药株对化疗药物变得敏感,使耐药蛋白的转运活性下降。结论中药具有逆转肿瘤MDR的活性,其作用机制大多是与耐药相关蛋白相关的。
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| 关 键 词： | 中药 多药耐药逆转 P-糖蛋白 多药耐药结合蛋白1 乳腺癌耐药蛋白 |
The research advance of traditional Chinese medicine to reverse the tumor multidrug resistance |
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| Institution: | CHENG Tao, SONG Xia, MA Yuanyuan, JIANG Yuanying, CAO Yongbing (1. Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China ; 2. China Pharmaceutical University, Nanjing 210009, China; 3. the Second Military Medical Uni versity, Shanghai 200433, China) |
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| Abstract: | Objective To review the research advance about the reversal of multidrug resistance （MDR） .Methods Herbal extracts and traditional Chinese medicine combined with chemotherapy drugs to reverse MDR were analyzed .Results Some herbal extracts or traditional Chinese medicine can improve the MDR strains sensitivity to chemotherapy ,and decrease the resistance protein trans-porter activity .Conclusion Some Chinese medicine has a reversing MDR tumor activity ,and its mechanism is mostly associated with the multidrug resistance-associated protein . |
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| Keywords: | traditional Chinese medicine multidrug resistance（MDR） reversal P-glycoprotein（P gp） multidrug resistance protein1 （MRP1） breast cancer resistance protein（BCRP） |
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