铁线莲皂苷体内抗肿瘤作用研究

目的:研究铁线莲皂苷的体内抗肿瘤作用。方法:采用肉瘤180(S180)、肝癌腹水型(HepA)和白血病腹水型(P388)3种小鼠移植性肿瘤模型进行试验。结果:铁线莲皂苷对小鼠移植性肿瘤S180,HepA,P388均有显著的抑制作用。当剂量为0.3,0.6,1.2g.kg^-1时,对小鼠移植性肿瘤S180抑制率分别为42.78%,52.06%,58.25%(P<0.05~0.01),对移植性肿瘤HepA抑制率分别为37.44%,52.05%,59.36%(P<0.05~0.001),对移植性肿瘤P388抑制率分别为34.50%,46.78%,54.39%(P<0.05~0.01)。结论:铁线莲皂苷对小鼠移植性肿瘤有显著的抑瘤作用。

Study on the anticancer activities of the Clematis manshrica Saponins in vivo

Objective: To study the anticancer activity of the Clematis manshrica saponins in vivo. Method: Anticancer activities were tested in mice with experimental tumor (S180,HepA and P388) in vivo. Result: The Clematis manshrica saponins showed a significant anticancer activities on Sarcoma-180, HepA and P388 implanted in mice. In S180 sarcoma, the average tumor inhibition rates were 42.78%, 52.06% and 58.25%(P<0.05-0.01) respectively; The mean inhibition rates were 37.44%, 52.05% and 59.36% (P<0.05-0.001) in Hep A tumor separately; while in P388 tumor, the mean inhibition rates were 34.50%, 46.78% and 54.39%(P<0.05-0.01),respectively. Conclusion: The results indicate that Clematis manshrica has obvious antitumor effects against various transplanted tumor in mice.