| 初生期异氟烷暴露对小鼠脑细胞发育、成年期行为、学习和记忆的影响 |
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| 引用本文： | Andreas W. Loepke,MD, PhD,FAAP,George K. Istaphanous,MD,John J. McAuliffe, Ⅲ, MD,MBA, FAAP,Lili Miles,MD,Elizabeth A. Hughes,BS,lohn C. McCann,BS,Kathrvn E. Harlow,BS,C. Dean Kurth,MD, FAAP,Michael T. Williams,PhD,Charles V. Vorhees,PhD,Steve C. Danzer,PhD,黎平[译],闵苏[校].初生期异氟烷暴露对小鼠脑细胞发育、成年期行为、学习和记忆的影响[J].麻醉与镇痛,2011(2):55-69,77. |
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| 作者姓名： | Andreas W. Loepke MD PhD FAAP George K. Istaphanous MD John J. McAuliffe Ⅲ MD MBA FAAP Lili Miles MD Elizabeth A. Hughes BS lohn C. McCann BS Kathrvn E. Harlow BS C. Dean Kurth MD FAAP Michael T. Williams PhD Charles V. Vorhees PhD Steve C. Danzer PhD 黎平[译] 闵苏[校] |
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| 作者单位： | [1]Departments of Anesthesia University of Cincinnati College of Medidne, Cindnnati, Ohio [2]Pathology, Cincinnati Children＇s Hospital Medical Center and University of Cincinnati College of Medidne, Cindnnati, Ohio [3]Department of Anesthesia, Cincinnati Children＇s Hospital Medical Center, Cindnnati, Ohio [4]Department of Pediatrics, Division of Neurology, Cindnnati Children＇s Research Foundation and University of Cindnnati College of Medidne, Cindnnati, Ohio [5]不详, Division of Neurology, Cindnnati Children＇s Research Foundation and University of Cindnnati College of Medidne, Cindnnati, Ohio |
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| 摘 要： | 背景 异氟烷等吸入麻醉药广泛地应用于婴幼儿.异氟烷、咪达唑仑以及氧化亚氮暴露后,新生小鼠神经变性和神经认知功能损害的一些研究,已经引起越来越多人对儿科麻醉安全问题的关注.新生小鼠异氟烷暴露较长时间会触发可致神经认知功能损害的低血糖症.本研究即检测初生期异氟烷暴露和血糖对小鼠的脑细胞存活力、自主活动能力以及空间学习记忆能...
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| 关 键 词： | 空间学习记忆能力 异氟烷 细胞发育 成年期 初生 鼠脑 Morris水迷宫法 认知功能损害 |
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