| Pharmacokinetic Study on Lovastatin Sustained-release Tablet and Sustained-release Capsule in Begal Dogs |
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| 作者姓名： | 付琳 代宗顺 侯淑贤 万元胜 |
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| 作者单位： | Department of Pharmacology，Tongji Medical College，of Huazhong University of Science and Technology，Department of Pharmacology，Tongji Medical College，of Huazhong University of Science and Technology，Department of Pharmacology，Tongji Medical College，of Huazhong University of Science and Technology，Department of Pharmacology，Tongji Medical College，of Huazhong University of Science and Technology Wuhan 430030，China，Wuhan 430030，China，Wuhan 430030，China，Wuhan 430030，China |
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| 摘 要： | LovastatinisanewcholesterolloweringdrugthatcompetitivelyinhibitsHMG CoAreductase ,whichisanearlyandrate limitingenzymeinthebiosynthesisofcholesterolinhepatocytes1 ] .In 1 987theFoodandDrugAdministrationapprovedthemarketingoflovastatin2 ] .Lovastatineffe…
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| 关 键 词： | 洛伐他汀 药物代谢动力学 缓释片 反相高效液相色谱法 动物模型 |
| 收稿时间： | 20 March 2003 |
Pharmacokinetic study on lovastatin sustained-release tablet and sustained-release capsule in Begal dogs |
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| Fu?Lin,Dai?Zongshun,Hou?Shuxian,Wan?Yuansheng.Pharmacokinetic Study on Lovastatin Sustained-release Tablet and Sustained-release Capsule in Begal Dogs[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2004,24(2):116-119. |
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| Authors: | Fu Lin Dai Zongshun Hou Shuxian Wan Yuansheng |
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| Institution: | Department of Pharmacology, Tongji Medical College, of Huazhong University of Science and Technology, Wuhan 430030, China |
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| Abstract: | Summary This study pharmacokinetically examined the lovastatin sustained-release tablet and sustained-release capsule in Beagle dogs.
An reversed-phase HPLC method was established for the determination of lovastatin in Beagle dog plasma. Pharmacokinetic findings
were compared among three preparation (lovastatin sustained-release tablet, Tp; sustained-release capsule, Tj and conventional capsule). Our results showed that the pharmacokinetic parameters in 6 dogs after single-dose oral administration
of three perparations were calculated. Tmax, Cmax and MRT revealed significant difference (P<0.05). Relative bioavailability was 111.5±16.9% (Tp) and 110.4%±9.6% (T1). The pharmacokinetic parameters in the 6 dogs after multiple-dose oral administration of three perparations, Tmax, Cmax MRT and DF had significant difference (P<0.05); Cav, Cmin and AUC0–24h displayed no significant difference (P>0.05). It is concluded that the lovastatin sustained-release tablet and sustained-release capsule are able to maintain a
sustained-release for 24 h.
FU Lin, female, born in 1975, Postgraduate Student |
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| Keywords: | lovastatin sustained-release tablets sustained-release capsules pharmacokinetic single-dose multiple-dose |
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