Myelofibrosis in patients with chronic myeloid leukemia treated with interferon-alpha |
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| Authors: | Kumas Sotiris Semenova E A Turkina A G Zakharova A V Domracheva E V Khoroshko N D Frank G A |
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| Affiliation: | Hematological Research Centre, 125187, Moscow. |
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| Abstract: | Trepanobiopsies of the bone marrow were studied in 46 patients in a chronic phase of chronic myeloid leukemia in different periods after the beginning of interferon-alpha therapy. Progression of myelofibrosis was observed in 2 cases only. Regression of myelofibrosis was observed in 14 cases of 29 (34.2%). A negative correlation between reticulin myelofibrosis and response to therapy was found. Disappearance of diffuse reticulin myelofibrosis in all cases was followed by a cytogenetic response. |
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