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| 唑来膦酸局部治疗对骨质疏松时自体髂骨移植内种植体骨结合的影响 | |
| 引用本文： | 李剑平,戚孟春,石燕萍,于静,胡静. 唑来膦酸局部治疗对骨质疏松时自体髂骨移植内种植体骨结合的影响[J]. 口腔医学研究, 2011, 27(1): 12-15 |
| 作者姓名： | 李剑平 戚孟春 石燕萍 于静 胡静 |
| 作者单位： | 1. 河北联合大学口腔医学院,河北,唐山,063000 2. 唐山工人医院内分泌科 3. 四川大学华西口腔医学院 |
| 基金项目： | 河北省科技厅科研项目(编号:08276101D-73); 河北省教育厅科研项目(编号:2008322) |
| 摘 要： | 目的：研究唑来膦酸局部治疗对骨质疏松时自体髂骨移植内种植体骨结合的影响。方法：30只雌性家兔随机分成A、B、C 3组。B、C组行双侧卵巢切除术,A组接受假手术。术后12周测量股骨骨密度（BMD）。在家兔右侧胫骨近中干骺端制备骨缺损,行自体髂骨移植及同期种植体植入术,A、B组植入HA涂层种植体,C组植入唑来膦酸钠涂层种植体。术后第2、12周处死动物,制作硬组织切片,进行组织形态学观察及骨计量学检测。结果：A、B组BMD显著低于C组（P〈0.01）。术后2周,B、C组间TCBI、BCR、BVC相似,均显著低于A组（P〈0.01）。术后12周,A组TCB、IBCR、BVC最高,C组次之,B组最低（P〈0.01）。和2周比较,12周时TCB除B组略降低外（P〈0.05）,A组和C组变化均不明显;IBCR各组均显著增高（P〈0.01）;而BVC则是B组降低（P〈0.05）,A组和C组显著增高（P〈0.01）。结论：唑来膦酸局部应用则可拮抗骨质疏松的影响,使种植体骨结合率增加。 |
| 关 键 词： | 种植牙 自体髂骨移植 骨质疏松 骨结合 兔 |
Effect of Local Treatment with Zoledronate Acid on Osseointegration of Dental Implants in Autologous Iliac Graft in Osteoporotic Rabbits |
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| LI Jian-ping,QI Meng-chun,SHI Yan-ping,et al.. Effect of Local Treatment with Zoledronate Acid on Osseointegration of Dental Implants in Autologous Iliac Graft in Osteoporotic Rabbits[J]. Journal of Oral Science Research, 2011, 27(1): 12-15 | |
| Authors: | LI Jian-ping QI Meng-chun SHI Yan-ping et al. |
| Affiliation: | LI Jian-ping,QI Meng-chun,SHI Yan-ping,et al.College of Stomatology,Hebei Union University,Tangshan 063000 |
| Abstract: | Objective: To investigate the effect of local treatment with zoledronate acid on osseointegration of dental implants in autologous iliac graft in osteoporotic rabbits.Methods: Thirty female rabbits were randomly divided into three groups: A,B and C.Animals in group B and C received bilatreal ovariectomy and group A underwent sham operation.12 weeks after surgery,femoral bones of rabbits were examined for bone mineral density to verify osteoporosis status.Then bone defects were made at the proximal metaphyse... |
| Keywords: | Dental implants Autologous iliac crest graft Osteoporosis Osseointegration Rabbit |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |