E选择素基因A561C多态性与2型糖尿病易感性的相关性研究 |
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引用本文: | 李艳,韦叶生,张平安,文重远,黄从新.E选择素基因A561C多态性与2型糖尿病易感性的相关性研究[J].中华内分泌代谢杂志,2005,21(1):51-54. |
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作者姓名: | 李艳 韦叶生 张平安 文重远 黄从新 |
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作者单位: | 1. 430060,武汉大学人民医院检验科 2. 430060,武汉大学人民医院内分泌科 3. 430060,武汉大学人民医院心内科 |
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基金项目: | 湖北省自然科学基金重点资助项目(2003ABA183) |
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摘 要: | 目的 探讨E选择素基因多态性在中国汉族人群中的分布及其与 2型糖尿病的关系。方法 应用PCR RFLP技术检测 110例 2型糖尿病和 115名健康对照者E选择素的基因型,以生物化学法测定他们的血糖、血脂水平。结果 E选择素基因型AA、AC频率在 2型糖尿病组和对照组分别为 0. 864、0. 136和 0. 948、0. 052;等位基因A、C频率在 2型糖尿病组和对照组分别为 0. 932、0. 068和 0. 974、0. 026。其基因型频率和等位基因频率在 2型糖尿病组和对照组比较差异均有统计学意义 (均P<0. 05)。基因型频率的相对风险分析发现,AC基因型患 2型糖尿病的风险是AA基因型 2. 868倍 (OR=2. 868, 95%CI:1. 070~7. 688)。E选择素基因型在中国汉族人群中的分布与国外报道的资料差异有统计学意义 (均P<0. 05)。结论 E选择素A561C基因多态性与 2型糖尿病的发病有相关性,C等位基因可能是 2型糖尿病的易感基因。
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关 键 词: | 2型糖尿病 E选择素 对照组 易感性 基因型 相关性研究 多态性 AC基因 中国汉族人群 等位基因频率 |
修稿时间: | 2003年6月27日 |
Association of A561C polymorphism of the E-selectin gene with susceptibility to type 2 diabetes mellitus |
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Abstract: | Objective To investigate the E selectin gene polymorphism in Chinese Han population and its association with type 2 diabetes mellitus (DM). Methods Genotype of E selectin was determined in 110 patients with type 2 DM and 115 healthy controls by PCR RFLP. Plasma glucose and lipid levels were measured by biochemical technique. Results E selectingenotypefrequenciesofAA,AC were 0.864, 0.136 in type 2 DM group and 0.948, 0.052 in control group respectively, and allele frequencies of A, C were 0.932, 0.068 in type 2 DM group and 0.974, 0.026 in control group respectively. There were significant differences in frequencies of allele and genotypeinE selectinA561Cpolymorphismbetweentype 2 DM group and control group (both P<0.05). The relative risk of AA genotype suffered fromtype2DMwas 2.868 times of the AC genotype (OR=2.868,95%CI: 1.070 7.688). There was significant difference in frequencie of genotype in E selectin between Chinese Han population and overseas data (all P<0.05). Conclusion E selectin A561C polymorphism is associated with type 2 DM and C allele appears to be a risk factor for type 2 DM in Chinese |
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Keywords: | Diabetes mellitus type 2 E-selectin Polymorphism (Genetics) |
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