Histamine release induced by histone and related morphological changes in mast cells |
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Authors: | K. Tasaka M. Mio M. Akagi T. Saito |
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Affiliation: | (1) Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, 700 Okayama, Japan |
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Abstract: | When isolated rat peritoneal mast cells were exposed to histone mixture, both histamine release and degranulation were evoked rapidly and dose-dependently at concentrations higher than 1 g/ml in a Ca-free medium. All of the histone subfractions (H1, H2A, H2B, H3 and H4) induced histamine release from mast cells in a Ca-free medium and, as in the case of histone mixture, the amount of histamine release was reduced by addition of Ca2+. By means of high-voltage electron microscopy, at least three types of degranulation were observed in mast cells exposed to histone mixture: (1) microfilament-associated degranulation, (2) extrusion of granules with the surrounding membrane, and (3) mass degranulation. |
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