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Treatment of steroid-resistant nephrotic syndrome in children: new guidelines from KDIGO |
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| Authors: | Rebecca M Lombel Elisabeth M Hodson Debbie S Gipson |
| Institution: | 1. Division of Nephrology, Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI, USA 5. Pediatric Nephrology, C.S. Mott Children’s Hospital, 1540 E. Hospital Drive, SPC 4297, Ann Arbor, MI, 48109-4297, USA 2. Centre for Kidney Research, The Children’s Hospital at Westmead, Westmead, Sydney, NSW, Australia 3. Sydney School of Public Health, University of Sydney, Sydney, NSW, Australia 4. Michigan Institute for Clinical and Health Research, University of Michigan, Ann Arbor, MI, USA |
| Abstract: | Kidney Disease: Improving Global Outcomes (KDIGO) recently published the clinical practice guideline on glomerulonephritis (GN) to assist the practitioner caring for patients with GN. Chapter 4 of the guideline focuses on managing children aged 1–18 years with steroid-resistant nephrotic syndrome (SRNS), defined by an inability to achieve complete remission with corticosteroid therapy. Guideline development followed a thorough evidence review, and management recommendations and suggestions were based on the best available evidence. Limitations of the evidence, including the paucity of large-scale randomized controlled trials, are discussed. This article provides both the guideline recommendations and a brief review of relevant treatment trials related to each recommendation. This précis serves as a summary of the complete guidelines recently published. |
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