芒果苷及其磷脂复合物大鼠在体肠吸收对比研究

目的]对比研究芒果苷及其磷脂复合物大鼠在体肠吸收情况,考察磷脂复合物对芒果苷肠吸收的影响。方法]选用大鼠在体单向肠灌流模型,以芒果苷为对照组,高效液相色谱(HPLC)法测定磷脂复合物在大鼠十二指肠、空肠、回肠及结肠的吸收。结果]芒果苷磷脂复合物在肠各吸收部位的吸收速率常数Ka和表观吸收系数Papp均大于芒果苷,其中在空肠的吸收均显著强于其他部位(P<0.01)。结论]与芒果苷相比,芒果苷磷脂复合物可改善大鼠的肠吸收。

Comparative study on absorption of mangiferin and its phosphate complex in intestine of rat

Objective] To compare the absorption of mangiferin and its phosphate complex in intestine of rats in vivo. The effect of phosphate complex on mangiferin. was investigated. Methods] The rat single-direction intestinal perfusion model in vivo was used. HPLC method was applied to measure the concentrations of mangiferin and its phosphate complex in intestine perfusate of duodenum, jejunum, ileum and colon, taking mangiferin as the control. Results] The absorption rate constant (K_a) and apparent absorption coefficient (P_app) of mangiferin phosphate complex in each intestinal segments were higher than that of mangiferin and had significant difference in jejunum (P<0.01). Conclusion] The intestinal absorption of mangiferin phosphate complex is superior to that of mangiferin.