氨甲喋呤与米非司酮联合治疗异位妊娠临床观察

目的 明确氨甲喋呤与米非司酮联合用药保守治疗异位妊娠的效果。方法 采取回顾性配对分析的方法,对氨甲喋呤与米非司酮联合用药和单一氨甲喋呤治疗异位妊娠的结果进行比较。结果 氨甲喋呤与米非司酮联合用药治疗异位妊娠的成功率为85％,未见比单一氨甲喋呤有所提高。但联合用药组用药后的血β-hCG降至正常的时间为(22.64±6.77)天,短于单一氨甲喋呤组血β-hCG降至正常的(27.22±6.11)天(P<0.05)。结论 氨甲喋呤与米非司酮联合用药与单用氨甲喋呤保守治疗异位妊娠的成功率相似。联合用药组用药后的血β-hCG降至正常的时间短于单用氨甲喋呤组。

Clinical observation of mifepristone in combination with methotrexate for the medical treatment of ectopic pregnancy

Objective To investigate the effect of mifepristone in combination with methotrexate for the medical treatment of ectopic pregnancy. Methods All patients with ectopic pregnancy for medical management were analysed retrospectively.Treatment consisted of methotrexate injected intramuscularly and 400 mg of mifepristone, administered orally,compared with a previous group who received only methotrexate alone.Results Success rate was 85% in combination group. Success rate was similar with that in methotrexate alone group.The time until Serum (3- hCG resolution in combination group was(22.64±6.77)d versus(27.22±6.11)d in methotrexate alone group( P <0.05). Conclusion The success rate of mifepristone in combination with methotrexate was similar to that of methotrexate alone. The time until Serum (3 - hCG resolution in combination group was shorter than that in methotrexate alone group.