Microscopic polyangiitis after silicone breast implantation |
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Authors: | Masayuki Iyoda Jyun Ito Hisako Nagai Kasumi Sato Aki Kuroki Takanori Shibata Kozo Kitazawa Tetsuzo Sugisaki |
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Affiliation: | (1) Department of Nephrology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan |
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Abstract: | We describe the case of a patient who developed microscopic polyangiitis (MPA) after silicone breast implantation. A 60-year-old woman who had undergone silicone breast implantation was admitted to our hospital with complaints of general malaise and hematoproteinuria. She was diagnosed as having MPA with evidence of acute progressive renal failure, pulmonary hemorrhage, and positivity for myeloperoxidase-antineutrophil cytoplasmic antibody (ANCA). A renal biopsy showed severe necrotizing and crescentic glomerulonephritis with arteriolitis. The patient received high-dose steroids and plasma exchange treatment, but died of progressive pulmonary hemorrhage and multiple cerebral hemorrhage. Silicone implantation is associated with scleroderma, systemic lupus erythematosus, and rheumatoid arthritis. This case report indicates the possibility of the development of MPA after silicone breast implantation. |
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Keywords: | Microscopic polyangiitis Human adjuvant disease Silicone breast implantation Silica ANCA |
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