| 细胞周期调控因子p16和CDK4在肺癌中的表达 |
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| 引用本文： | 路名芝,刘勇.细胞周期调控因子p16和CDK4在肺癌中的表达[J].中国癌症杂志,2001,11(2):123-124. |
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| 作者姓名： | 路名芝 刘勇 |
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| 作者单位： | 江西省人民医院病理科, |
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| 基金项目： | 江西省卫生厅科研基金(No.980021)资助。 |
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| 摘 要： | 目的探讨肺癌中细胞周期调控因子p16和CDK4的表达意义。方法应用S-P免疫组织化学方法检测62例肺癌组织中p16和CDK4的表达情况。结果62例肺癌组织中p16和CDK4阳性率分别为58.1%和48.4%。腺癌中p16的阳性率明显高于小细胞癌(P＜0.05)；淋巴结转移阳性组p16的表达显著低于阴性组(P＜0.05，r=0.27)。不同组织类型肺癌中CDK4的表达未见明显差异，淋巴结转移阳性组CDK4的表达高于阴性组(P＜0.01，r=0.58)。p16和CDK4的表达呈明显负相关(P＜0.01，r=-0.81)。结论提示p16的表达与肺癌的组织学类型有关，CDK4高表达对肺癌细胞的淋巴结转移起重要作用。
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| 关 键 词： | 肺肿瘤 基因表达 肿瘤转移 免疫组织化学 p16 CDK4 细胞周期 调控因子 |
| 文章编号： | 1007-3639(2001)02-0123-02 |
| 修稿时间： | 2000年7月31日 |
Expression of p16 and CDK4 in human lung carcinoma |
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| LU Ming-zhi,LIU Yong.Expression of p16 and CDK4 in human lung carcinoma[J].China Oncology,2001,11(2):123-124. |
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| Authors: | LU Ming-zhi LIU Yong |
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| Abstract: | Purpose:To study the expressions of p16 and CDK4 in human lung carcinoma. Methods:By using S-P immunohistochemical methods, the expressions of p16 and CDK4 in 62 cases of human lung carcnoma were studied. Results:The postive expressions for p16 and CDK4 protein were 58.1% and 48.4% respectively. A significant correlation was found between CDK4 overexpression and lymph node metastasis ( P <0 01). A significant correlation between the under expression of p16 and overexpression of CDK4 was found.Conclusions:The results suggested that CDK4 overexpression plays an important role in metastasis of lung carcinoma. |
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| Keywords: | lung tumor gene metastasis immunohistochemistry |
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