| 乳腺癌分子亚型中BRCA1的表达及其与雌激素受体的关系 |
| |
| 引用本文： | 肖璇,刘慧,范钦和.乳腺癌分子亚型中BRCA1的表达及其与雌激素受体的关系[J].临床与实验病理学杂志,2009,25(1). |
| |
| 作者姓名： | 肖璇 刘慧 范钦和 |
| |
| 作者单位： | 南京医科大学第一附属医院病理科,南京,210029;南京医科大学病理系,210029 |
| |
| 基金项目： | 江苏省卫生厅科技发展基金 |
| |
| 摘 要： | 目的 研究BRCA1在乳腺癌分子亚型中表达特点及其与雌激素受体的关系.方法 1 452例乳腺癌标本制作组织芯片,免疫组织化学MaxVision快捷法检测ER、PR、HER2、CK5/6、EGFR的表达,按照Nielsen标准进行分子分型.免疫组织化学MaxVision快捷法检测BRCA1的表达水平.结果 腺腔A型,腺腔B型,基底样型,HER2过表达型和裸表达型分别为428例、56例、223例、188例、416例.BRCA1在腺腔A型,腺腔B型,基底样型,HER2过表达型,裸表达型中的表达率分别86.9%(358/412), 87.5%(49/56), 63.0%(136/216), 70.4%(131/186), 60.4%(246/407).BRCA1在基底样型乳腺癌、HER2过表达型和裸表达型中的表达率低于ER阳性乳腺癌腺腔A型(P<0.001)和腺腔B型(P<0.001),BRCA1的阳性表达与ER的阳性表达相关(P<0.001).结论 BRCA1在基底样型乳腺癌和其他ER阴性乳腺癌亚型中的表达下调,其功能异常可能参与ER阴性乳腺癌分子亚型的发生.
|
| 关 键 词： | 乳腺肿瘤 分子亚型 受体 雌激素 |
Expression of BRCA1 in molecular subtypes of breast carcinoma and its relationship with ER |
| |
| XIAO Xuan,LIU Hui,Fan Qin-he.Expression of BRCA1 in molecular subtypes of breast carcinoma and its relationship with ER[J].Chinese Journal of Clinical and Experimental Pathology,2009,25(1). |
| |
| Authors: | XIAO Xuan LIU Hui Fan Qin-he |
| |
| Institution: | Department of Pathology;the First Affiliated Hospital of Nanjing Medical University;Nanjing 210029;China |
| |
| Abstract: | Purpose To study the expression of BRCA1 in the molecular subtypes of breast carcinoma and the relationship between BRCA1 and ER.Methods Immunohistochemistry was used to detect the expression of ER,PR,HER2,CK5/6 and EGFR on a tissue microarray containing 1 452 cases of invasive breast carcinomas.Based on the results,the cases were categorized according to Nielson criteria.The expression of BRCA1 was also detected by immunohistochemical MaxVision method.Results Of 428 cases,56,223,188 and 416 were classified... |
| |
| Keywords: | BRCA1 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
