| 减少房水分泌对眼前房免疫赦免和角膜移植免疫排斥反应的影响 |
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| 引用本文： | 李志杰 李辰. 减少房水分泌对眼前房免疫赦免和角膜移植免疫排斥反应的影响[J]. 眼科, 1997, 6(3): 180-181,158 |
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| 作者姓名： | 李志杰 李辰 |
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| 作者单位： | 暨南大学组织移植与免疫中心眼科学教研室!510632，广州，暨南大学组织移植与免疫中心眼科学教研室!510632，广州 |
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| 基金项目： | 国家自然科学基金，广东省自然科学基金 |
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| 摘 要： | 本实验在兔眼建立睫状体冷冻术模型，观察了睫状破坏和减少房水分地眼前房免疫郝免状态，以及角膜移植存活的影响，结果显示：冷冻伤术后６周眼房水的免疫制活性显著下降；ＡＣＡＩＤ现象消失，与正常对照组相比，免疫排斥反应加速植片存活时间缩短，结果提示：正常睫状体的组织结构及分泌的房水及对于维持和介导前房免疫郝免，以及角膜移植的长期存活起着重要作用。这为进一步阐明角膜移植免疫排斥反应机制，并制定相应预防措施提供
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| 关 键 词： | 眼房水 角膜移植 排斥反应 免疫赦免 |
Effects of the decreased secretion of aqueous humor on anterior chamber immune priviledge and corneal graft survival |
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| Li Zhijie. Effects of the decreased secretion of aqueous humor on anterior chamber immune priviledge and corneal graft survival[J]. Ophthalmology in China, 1997, 6(3): 180-181,158 |
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| Authors: | Li Zhijie |
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| Abstract: | To evaluate effects of the decreased secretion of aqueous humor on anterior chamber immune privilege and corneal graft survival, a model of cryocautery of the ciliary body of normal rabbit eye was established.We found that the immunosuppressive levels of aqueous humor of eyes 6 weeks after being frozen significantly decreased; ACAID disappeared; compared with the control group, corneal grafts were rejected at a high speed and their survival time was shortened. Our findings show that the normal anterior chamber and its secretion of aqueous humor play an important role in maintaining its normal immune priviledge status and the survival of corneal graft. |
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| Keywords: | Aqueous humor Corneal transplantation Graft rejection Immune priviledge |
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