| 角膜基质细胞对淋巴细胞活化的抑制效应 |
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| 引用本文： | 李志杰,李辰.角膜基质细胞对淋巴细胞活化的抑制效应[J].眼科,1997,6(4):236-237. |
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| 作者姓名： | 李志杰 李辰 |
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| 作者单位： | 暨南大学组织移植与免疫中心!眼科学教研室，广州，510632，暨南大学组织移植与免疫中心!眼科学教研室，广州，510632 |
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| 摘 要： | 建立人、大鼠和兔角膜基质细胞的原代和传代２。在基质细胞单层上观察了淋巴细胞对丝裂原刺激的增殖反应和单向混合淋巴细胞反应，并进一步分析了基质细胞与细胞培养上清对淋巴细胞活化的影响。结果显示：不同种系来源的角膜基质细胞和细胞上清对小鼠淋巴细胞具有同样的免疫抑制效应，提示：角膜细胞以及产生的可溶怀免疫抑制介质对于角膜移植片免受免疫活性细菌识别和攻击，以及长期存活可能起关一定的作用。
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| 关 键 词： | 角膜移植 角膜基质细胞 淋巴细胞 移植免疫学 |
Inhibitory effect of corneal stromal fibroblasts on lymphocyte activation |
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| Li Zhijie Ophthalmol CHN. -.Inhibitory effect of corneal stromal fibroblasts on lymphocyte activation[J].Ophthalmology in China,1997,6(4):236-237. |
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| Authors: | Li Zhijie Ophthalmol CHN - |
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| Institution: | Li Zhijie Ophthalmol CHN. -1997,6 |
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| Abstract: | To evaluate the effect of corneal stromal fibroblasts on lymphocyte activation,coculture of corneal stromal fibroblasts isolated from human,rat and rabbit cornea respectively with mouse splenocytes in the presence of Concanavalin A(ConA) or with mouse allogeneic mixed lymphocyte was performed. We found that corneal stromal fibroblasts and corneal fibroblast-conditioned medium inhibited the proliferative response of lymphocytes to ConA and alloantigens.Our results suggest that corneal stromal fibroblasts and their products of soluble inhibitory factor or factors play a role in prolonging corneal allograft survial. |
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| Keywords: | Cell cultured Immunosuppression Lymphocyte transformation |
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