| 川芎嗪和顺铂联用对小鼠Lewis肺癌生长和转移的抑制作用 |
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| 引用本文： | 符慧群,唐雪元,潘宇亮.川芎嗪和顺铂联用对小鼠Lewis肺癌生长和转移的抑制作用[J].南华大学学报(医学版),2008,36(1):46-49. |
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| 作者姓名： | 符慧群 唐雪元 潘宇亮 |
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| 作者单位： | 1. 中南大学,湘雅三医院,肿瘤科,湖南,长沙,410013
2. 中南大学,湘雅三医院,血液内科 |
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| 摘 要： | 目的探讨川芎嗪联合顺铂对小鼠Lewis肺癌生长和转移的抑制作用及其机制。方法将40只接种Lewis肺癌的C57BL小鼠随机分成4组：对照组、顺铂组、川芎嗪组及联合用药组，每组10只，连续用药20天，于接种后第22天处死全部小鼠，剥离皮下肿瘤称瘤重并计算抑瘤率，取出双肺观察表面肿瘤转移情况，计算肿瘤肺转移发生率、肺表面转移结节数及肺表面结节转移抑制率，采用免疫组化检测肿瘤组织微血管密度（MVD）及P-选择素的表达水平。结果各用药组肿瘤的生长明显受到抑制，瘤重明显低于对照组（P〈0．01），联合用药组抑瘤率明显高于顺铂组和川芎嗪组（P〈0．05），各用药组肺表面转移结节数及转移发生率明显低于对照组（P〈0．05或0．01）；联合用药组肺表面结节转移抑制率明显高于顺铂组和川芎嗪组（P〈0．05）。川芎嗪组、联合用药组MVD及P-选择素表达水平显著低于对照组（P〈0．01）。结论川芎嗪可明显抑制Lewis肺癌细胞在小鼠体内的生长和转移，与顺铂联用有协同作用，其作用机制可能与抑制微血管生成和降低P-选择素表达有关。
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| 关 键 词： | 川芎嗪 顺铂 肺肿瘤 P-选择素 |
Inhibitory Effect of Tetramethylpyrazine in Combination With Cisplatin on Growth and Metastasis of Lewis Lung Carcinoma in Mice |
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| HU Hui-qun,TANG Xue-yuan,PAN Yun-liang.Inhibitory Effect of Tetramethylpyrazine in Combination With Cisplatin on Growth and Metastasis of Lewis Lung Carcinoma in Mice[J].Journal of Nanhua University(Medical Edition),2008,36(1):46-49. |
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| Authors: | HU Hui-qun TANG Xue-yuan PAN Yun-liang |
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| Institution: | HU Hui-qun,TANG Xue-yuan,PAN Yun-liang(Department of Oncology,the Third Xiangya Hospital,Central South University,Changsha,Hunan 410013,China) |
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| Abstract: | Objective To explore the inhibitory effect and mechanism of tetramethylpyrazine in combination with cisplatin on growth and metastasis of Lewis lung carcinoma in mice. Methods The Lewis lung carcinoma models of C57BL mice were established.Forty T739 mice were randomly divided into 4 groups: control group(Group A),cisplatin group(Group B),tetramethylpyrazine group(Group C) and combination group(Group D).Every group had 10 mice.Different treatments were served from day 2 after transplantation and all mice wer... |
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| Keywords: | tetramethylpyrazine cisplatin lung neoplasm P-selectin |
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