大鼠冲击伤时肺超微结构的变化

本实验应用硝酸镧示踪等电镜技术观察了大鼠冲击伤时肺血-气屏障通透性及超微结构的变化。结果表明致伤组动物(1)肺泡上皮细胞和毛细血管内皮细胞及其细胞连接的通透性显著增加;(2)肺泡上皮细胞及毛细血管内皮细胞肿胀,饮液小泡数量增多、空泡形成及细胞破坏;(3)出现血小板聚集和中性白细胞扣押。上述变化以内皮细胞部位及伤后72小时较为明显。这些表明内皮细胞对冲击波较为敏感;内皮细胞损伤重可能与血小板聚集和中性白细胞扣押有关。

Ultrastructural changes in rat lung with blast injury

The experimental blast lung injuries are as follows: 1.permiability of the alveolar epithclium(AE),capillary endothelium(CE) and their intercellular junctions increased; 2.small vacuoles,large vacuoles formation and cell membrane damage in the AE and CE increased in amounts; 3.blood platelets aggregated and neutrophils trapped in the capillary lumen.These changes are more serious in the CE and especially 72 h after trinitrotoluene(TNT)explosions.These suggest that the CE is more sensitive to blast injury than AE,and the CE damage may be related to the neutrophils trapping and platelets aggregation in the capillary lumens.