|
|||||
|
|
A high-throughput approach towards a novel formulation of fenofibrate in omega-3 oil |
|
| Authors: | Pasut Ratanabanangkoon Hector Guzman Orn Almarsson Dina Berkovitz Stephanie Tokarcyzk Arthur B. Straughn Hongming Chen |
| Affiliation: | aTransForm Pharmaceuticals, Inc., 29 Hartwell Avenue, Lexington, MA 02421, United States bDepartment of Pharmaceutical Sciences, Drug Research Laboratory, University of Tennessee Health Science Center, Memphis, TN, United States |
| Abstract: | A novel lipid formulation containing fenofibrate in omega-3 oil was developed using a novel high-throughput screening platform. The optimized formulation combines the cardiovascular health benefits from omega-3 oil with the potent lipid-regulating effect of fenofibrate. When tested against the current marketed product Tricor® in healthy human volunteers, the new formulation was shown to be equivalent to Tricor®. |
| Keywords: | High-throughput screening (HTS) Fenofibrate Self-emulsifying drug-delivery systems (SEDDS) Omega-3 Lipid formulation |
| 本文献已被 ScienceDirect 等数据库收录！ | |