| 人外周血循环卵泡抑素mRNA水平的随龄变化 |
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| 引用本文： | 王奭骥,王永香,崔雪玲,柳忠辉,台桂香.人外周血循环卵泡抑素mRNA水平的随龄变化[J].中国老年学杂志,2007,27(5):404-405. |
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| 作者姓名： | 王奭骥 王永香 崔雪玲 柳忠辉 台桂香 |
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| 作者单位： | 吉林大学基础医学院免疫学教研室,吉林,长春,130021 |
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| 摘 要： | 目的探讨人外周血循环中卵泡抑素(Follistatin,FS)水平的增龄性变化。方法采用实时定量RT-PCR检测不同年龄组健康成年人外周血循环FS mRNA水平。结果循环血中FS mRNA水平与年龄呈正相关,随增龄循环FS mRNA水平也呈增加趋势;健康成年人外周血中FS蛋白水平也与年龄呈正相关,随增龄FS水平也呈增加趋势。结论采用实时定量RT-PCR检测健康成年人外周血循环FS mRNA水平,与检测FS蛋白水平的临床意义一致,而且实时定量RT-PCR更快捷、特异。
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| 关 键 词： | 卵泡抑素 循环mRNA 增龄 |
| 文章编号： | 1005-9202（2007）05-0404-02 |
| 收稿时间： | 2006-09-14 |
| 修稿时间： | 2006-10-16 |
Changes of the peripheral blood circulating FS mRNA levels with age in human |
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| WANG Shi-Ji, WANG Yong-Xiang, CUI Xue-Ling,et al..Changes of the peripheral blood circulating FS mRNA levels with age in human[J].Chinese Journal of Gerontology,2007,27(5):404-405. |
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| Authors: | WANG Shi-Ji WANG Yong-Xiang CUI Xue-Ling |
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| Institution: | Department of Immunology, School of Basic Medical Sciences, Jilin University, Jilin Changchun 130021, Jilin, China |
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| Abstract: | Objective To investigate the changes in human peripheral blood circulating follistatin (FS) mRNA with ageing.Methods The levels of circulating FS mRNA in sera of healthy adults were detected by real-time quantitative RT-PCR. Results The circulating FS mRNA levels was positive relation to ageing, and had increase tendency with ageing; and changes of FS protein levels in healthy adults had also a trend to increase with ageing.Conclusions The detection of the circulating FS mRNA levels in human sera by real-time RT-PCR might have same clinical significance as that of the mature FS protein in the peripheral blood, and real-time RT-PCR is more quick and specific. |
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| Keywords: | RT-PCR |
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