| Ames试验检测三硝基甲苯及其还原代谢产物的诱变性 |
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| 引用本文： | 李斌 吴琼. Ames试验检测三硝基甲苯及其还原代谢产物的诱变性[J]. 工业卫生与职业病, 1997, 23(1): 27-30 |
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| 作者姓名： | 李斌 吴琼 |
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| 作者单位： | 兵器工业卫生研究所!西安丈八东路1号，710065 |
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| 摘 要： | 应用Ａｍｅｓ试验检测系统观察了三硝基甲苯及其还原代谢产物４－羟氨基－２，６－二硝基甲苯（４－ＨＡ），４－氨基－２，６－二硝基甲苯（４－Ａ），２－氨基－４，６－二硝基甲苯（２－Ａ）和２，４－二氨基－６－硝基甲苯（２，４－ＤＡ）的诱变活性，实验结果显示，三硝基甲苯及其代谢产物具有明显的致突变作用，４－Ａ的直接诱变活性最强，而且移码型诱变性更为显著，在微粒体酶系统的参与下，ＴＮＴ的诱变活性增强，其代谢产
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| 关 键 词： | 三硝基甲苯 代谢产物 Ames试验 |
STUDY ON MUTAGENICITY OF TNT AND ITS REDUCTIVE METABOLITES BY AMES TEST |
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| Li Bin et al. STUDY ON MUTAGENICITY OF TNT AND ITS REDUCTIVE METABOLITES BY AMES TEST[J]. Industrial Health and Occupational Diseases, 1997, 23(1): 27-30 |
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| Authors: | Li Bin et al |
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| Abstract: | The mutagenicity of TNT and its metabolites 4-hydroxylamino-2, 6-dinitrotoluene (4-HA), 4-amino- 2, 6-dinitrotoluene (4-A), 2-amino-4, 6-dinitrotoluene (2-A) and 2, 4-diamino-6-nitrotoluene (2,4-DA) has been detected with Ames test. The results showed that TNT and its metabolites all have remarkable mutagenicity. The direct mutagenicity of 4-A is the highest. Indirect mutagenicity of TNT elevates significantly in the presence of S-9mix and it is higher than that of 4-A. Reductive activation of 4-nitro group and direct mutagenicity of 4-amino compounds are of importance for mutagenic activity of TNT. |
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| Keywords: | TNT Metabolite Ames test |
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