中国肾综合征出血热疫苗近期防病效果

对中国试生产的肾综合征出血热沙鼠肾细胞Ⅰ型灭活疫苗（上海生研所和天元公司）、乳鼠脑纯化Ⅰ型灭活疫苗（兰州生研所）和地鼠肾细胞Ⅰ型灭活疫苗（长春生研所），在疫区进行了人群接种，并对其安全性、血清学和近期防病效果进行了考核。结果表明，三种疫苗安全性皆较好，上海沙鼠苗、天元沙鼠苗、鼠脑苗和地鼠苗中强反应率分别为0.56%、0.03%、3.26%和1.57%。三种疫苗三针全程免疫后14天，其中和抗体阳转率地鼠苗79.04%、上海沙鼠苗58.33%、天元沙鼠苗70.00%、鼠脑苗50.00%；荧光抗体阳转率地鼠苗65.57%、上海沙鼠苗93.69%、天元沙鼠苗83.33%、鼠脑苗83.53%。三种疫苗近期防病诳果均较好，其保护率:地鼠苗79.19%、上达沙鼠苗95.81%、天元沙鼠苗96.60%％、鼠脑苗95.39%。

A Comparative Study on the short-term Preventive Effect of Hemorrhagic Fever with Renal Syndrom(HFRS)Vaceine in China

A comparative study on the safety，serological and short-term epidemiologiqal ef-fects of HFRS vaccines including inactivated Mongolial Gerbals Kidney Cell Type I vaccine(pro-duced by Shanghai Institute of Biological Product and Tianyuan Company),inactiveted purified suckling mouse brain Type I vaccine(produced by Lanzhou InstRute of Biological Products and Inactivated Hamster kidney Cell Type I vaccine(produced by Changchun Institute of Biological products)was carried out in the residents of infectious loci of HFRS．The results indicated that all of these 3 vaccines had good safety．the post vaccination reactions of these vaecines were 0.03～0.56％，3.26％and 1.57 resectively．The serum conversion rates ofneutralizing antiodies against HFRS after 14 days mmunization of the above vaccines were 58.33％～70.0%，50％ and 79.04％respectively．The conversion rates of Immunofluoresccne Antibody of above vaccines were 83.33％～93.69％，83.53％and 65.57％respectively．The short-term preventive effects of all the above 3 vaccines were 95.81％～96.60％，95.39％and 97.19％respetively。