| 激活Notch信号的骨髓间充质干细胞心肌移植促进血管新生 |
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| 引用本文： | 谢雄伟,马树人.激活Notch信号的骨髓间充质干细胞心肌移植促进血管新生[J].江苏医药,2011,37(14). |
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| 作者姓名： | 谢雄伟 马树人 |
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| 作者单位： | 南京医科大学附属淮安市第一人民医院心脏病科,淮安市,223300 |
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| 基金项目： | 湖南省教育厅科学研究重点资助项目[湘财(2006)36号] |
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| 摘 要： | 目的探讨干预Notch信号骨髓间充质干细胞(BMSCs)移植对心肌梗死(MI)大鼠心肌的治疗性血管新生作用及其机制。方法 60只Wistar大鼠经结扎冠状动脉前降支建立MI模型后2周进行相应处理后,随机分为激活Noth信号的BMSCs移植实验组(D组)、BMSCs移植对照组(E组)、培养液移植对照组(C组)、MI模型对照组(B组),每组15只;另选取10只为假手术对照组(A组)。4周后观察细胞生长及增殖情况,测定缺血心肌中血管内皮细胞生长因子(VEGF)蛋白的表达及缺血区心肌毛细血管密度的改变。结果 BMSCs在梗死区中可增殖分化为内皮细胞。与B组、C组及A组相比,D组、E组缺血心肌中VEGF蛋白的表达增多及毛细血管密度均明显增高(P<0.01),D组较E组更明显(P<0.05)。结论 Notch信号促进心肌梗死区BMSCs向内皮细胞分化,促进缺血心肌中毛细血管新生。
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| 关 键 词： | Notch信号 骨髓间充质干细胞 心肌梗死 血管新生 |
Myocardium transplantation with Notch signal-activated bone mesenchymal stem cells promotes vasa sanguinea neogenesis |
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| XIE Xiongwei,MA Shuren.Myocardium transplantation with Notch signal-activated bone mesenchymal stem cells promotes vasa sanguinea neogenesis[J].Jiangsu Medical Journal,2011,37(14). |
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| Authors: | XIE Xiongwei MA Shuren |
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| Institution: | XIE Xiongwei,MA Shuren.Department of Cardiology,Affiliated First Huaian Hospital,Nanjing Medical University,Huaian 223300,CHINA |
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| Abstract: | Objective To investigate the effect and mechanism of transplantation of Notch signal-activated bone mesenchymal stem cells(BMSCs) into myocardium after myocardial infarction(MI) to promote vasa sanguinea neogenesis.Methods MI model was established in 60 Wistar rats by ligation of left anterior descending(LAD),which were randomly divided into groups of D(with Notch signal-activated BMSCs transplantation),E(BMSCs transplantation control),C(culture medium transplantation control) and B(MI model control) with 1... |
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| Keywords: | Notch signal Bone mesenchymal stem cells Myocardial infarction Vasa sanguinea neogenesis |
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