| CK19、Galectin-3和HBME-1在甲状腺乳头状癌中的表达及意义 |
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| 引用本文： | 顾春燕,肖锋,钱金锋,孙艳,刘宏斌. CK19、Galectin-3和HBME-1在甲状腺乳头状癌中的表达及意义[J]. 江苏医药, 2011, 37(13) |
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| 作者姓名： | 顾春燕 肖锋 钱金锋 孙艳 刘宏斌 |
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| 作者单位： | 1. 南通大学附属南通第三医院病理科,226006
2. 南通市第一人民医院病理科 |
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| 摘 要： | 目的探讨细胞角蛋白19(CK19)、Galectin-3和HBME-1在甲状腺乳头状癌(PTC)和乳头状增生性甲状腺疾病鉴别诊断中的作用。方法应用免疫组织化学方法检测了44例PTC、27例结节性甲状腺肿伴乳头状增生(NGWPH)和40例甲状腺腺瘤伴乳头状增生(FAWPH)中单克隆抗体CK19、Galectin-3和HBME-1的表达。结果 CK19、Galectin-3和HBME-1在PTC中的阳性表达率分别为100%、97.7%和95.5%,均明显高于NGWPH中的11.1%、7.4%和3.7%,或FAWPH中的12.5%、2.5%和10.0%(P<0.01)。同一病例有两种以上阳性表达在PTC为97.7%,明显高于NGWPH和FAWPH的11.1%和7.5%(P<0.01)。结论 CK19、Galectin-3和HBME-1的检测,尤其是联合检测,对甲状腺良、恶性病变的诊断及鉴别诊断具有较高的临床使用价值。
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| 关 键 词： | 甲状腺乳头状癌 甲状腺乳头状增生 细胞角蛋白19 Galectin-3 HBME-1 |
Expression and significance of detecting cytokeratin 19,galectin-3,HBME-1 in papillary thyroid carcinoma |
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| GU Chunyan,XIAO Feng,QIAN Jinfeng,et al.. Expression and significance of detecting cytokeratin 19,galectin-3,HBME-1 in papillary thyroid carcinoma[J]. Jiangsu Medical Journal, 2011, 37(13) |
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| Authors: | GU Chunyan XIAO Feng QIAN Jinfeng et al. |
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| Affiliation: | GU Chunyan,XIAO Feng,QIAN Jinfeng,et al.Department of Pathology,Affiliated Nantong Third Hospital,Nantong University,Nantong 226006,CHINA |
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| Abstract: | Objective To investigate the expression and significance of detecting cytokeratin 19(CK19),galectin-3,HBME-1 in the diagnosis of papillary thyroid carcinoma(PTC).MethodsImmunohistochemical staining was performed in 44 PTC samples,27 nodular goiter with papillary hyperplasia samples(NGWPH) and 40 follicular adenoma with papillary hyperplasia samples(FAWPH).Results The expressions of CK19,galectin-3 and HBME-1 were 100%,97.7% and 95.5% in PTC,which were higher than 11.1%,7.4% and 3.7% in NGWPH and 12.5%,2.5% ... |
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| Keywords: | Papillary thyroid carcinoma Thyroid papillary hyperplasia Cytokeratin 19 Galectin-3 HBME-1 |
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