| Abelson相关基因在大肠癌中的表达及其临床意义 |
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| 引用本文： | 许波涛,顾晓华,毛勤生,朱建伟. Abelson相关基因在大肠癌中的表达及其临床意义[J]. 江苏医药, 2011, 37(13) |
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| 作者姓名： | 许波涛 顾晓华 毛勤生 朱建伟 |
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| 作者单位： | 1. 江苏省如皋博爱医院普通外科,226500
2. 南通大学附属医院普通外科 |
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| 基金项目： | 国家自然科学基金(30771126); 教育部回国留学人员基金(2008-890); 江苏省自然科学基金(BK2006058) |
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| 摘 要： | 目的探讨Abelson相关基因(Arg)在人大肠癌组织中的表达及其意义。方法免疫组织化学染色法检测80例大肠癌组织、30例癌旁大肠组织和30例大肠腺瘤中Arg的表达,并分析Arg表达水平与临床病理特征的相关性。结果 Arg在大肠癌组织中阳性表达率为70%,癌旁结肠组织和大肠腺瘤组织均无Arg表达。Arg表达与大肠癌的分化程度、浸润深度、淋巴结转移、TNM分期及癌胚抗原(CEA)水平有关(P<0.05),Arg高表达者生存期低(P<0.05)。结论 Arg可能在大肠癌发病过程中起重要作用,可作为大肠癌预后判断的有价值指标之一。
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| 关 键 词： | 大肠癌 Abelson相关基因 |
Expression and significance of Abelson-related gene in colorectal cancer |
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| XU Botao,GU Xiaohua,MAO Qinsheng,et al.. Expression and significance of Abelson-related gene in colorectal cancer[J]. Jiangsu Medical Journal, 2011, 37(13) |
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| Authors: | XU Botao GU Xiaohua MAO Qinsheng et al. |
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| Affiliation: | XU Botao,GU Xiaohua,MAO Qinsheng,et al.Department of General Surgery,Boai Hospitalof Rugao,Rugao 226500,CHINA |
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| Abstract: | Objective To investigate the expression and significance of Abelson-related gene(Arg) in human colorectal cancer.Methods The expression of Arg was examined by immunohistochemistry in colorectal cancer tissues(80 cases),tumor-adjacent normal tissues(30 cases) and colorectal adenomas(30 cases).The correlation of Arg expression with clinicopathologic features of colorectal cancer was analyzed.Results The positive expression rate of Arg in the adenocarcinomas was 70%,which was zero in the tumor-adjacent normal ... |
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| Keywords: | Colorectal cancer Abelson-related gene |
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